Effects of zearalenone on oxidative stress and inflammation in weanling piglets

被引：114

作者：

Marin, Daniela E. ^{[1
]}

Pistol, Gina C. ^{[1
]}

Neagoe, Ionela V. ^{[2
]}

Calin, Loredana ^{[1
]}

Taranu, Ionelia ^{[1
]}

机构：

[1] Natl Inst Res & Dev Biol & Anim Nutr, Lab Anim Biol, Balotesti 077015, Ilfov, Romania

[2] Natl Inst Pathol Victor Babes, Bucharest 050096, Romania

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2013年 / 58卷

关键词：

Zearalenone; Swine; Oxidative stress; Inflammation; MYCOTOXIN ZEARALENONE; ALPHA-ZEARALENOL; FUSARIUM TOXINS; CHROMOSOME-ABERRATIONS; BIOCHEMICAL PARAMETERS; CONTAMINATED DIETS; IMMUNE-RESPONSE; GENE-EXPRESSION; BETA-ZEARALENOL; GRANULOSA-CELLS;

D O I：

10.1016/j.fct.2013.05.033

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin produced by the fungi of Fusarium genera. Piglets were fed for 18 days with a control or a ZEN (316 ppb) contaminated diet. At the end of the experiment tissue samples were taken for assessment of: lymphocyte proliferation, monocytes and granulocytes respiratory burst, inflammatory cytokine synthesis in blood and liver, expression of genes involved in oxidative stress or in inflammation, plasma biochemical parameters, total antioxidant status and nitric oxide synthesis. In blood, ZEN increases the respiratory burst of monocytes and the inflammatory cytokine (TNF alpha, IL-1 beta, IFN gamma) synthesis, while in liver, ZEN decreases the synthesis of all inflammatory cytokines investigated. In liver and spleen, different effect on the expression of genes involved in oxidative stress and inflammation was observed. While in liver, ZEN decrease the expression of cyclooxigenase gene, but increase the expression of glutathione peroxydase and catalase genes; in spleen, ZEN induces a decrease of the superoxide dismutase gene expression together with an increase of the cyclooxigenase. In conclusion, our results showed that liver, spleen and blood may also be target tissues in weanling piglets fed ZEN contaminated diet, with different effects on oxidative stress and inflammation. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：408 / 415

页数：8

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