Asymmetric Henry Reactions of Aldehydes Using Chiral Biaryl-Based Bis(thiourea) Organocatalysts

被引：11

作者：

Nakayama, Yuki ^{[1
]}

Hidaka, Yusaku ^{[1
]}

Ito, Katsuji ^{[1
]}

机构：

[1] Fukuoka Univ Educ, Dept Chem, Fukuoka 8114192, Japan

来源：

SYNLETT | 2013年 / 24卷 / 07期

关键词：

asymmetric catalysis; bis(thiourea); Henry reaction; nucleophilic addition; enantioselectivity; NITROALDOL REACTION; CU-II; GUANIDINE; CATALYST; COMPLEXES; LIGANDS; DESIGN; SALT;

D O I：

10.1055/s-0032-1318490

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Biaryl-based bis(thiourea) was found to be an efficient organocatalyst for the asymmetric Henry reaction. High enantioselectivity of up to 93% ee was obtained for the reaction of nitromethane with aryl aldehydes when the combination of N,O-bis(trimethylsilyl)trifluoroacetoamide (BSTFA) with a catalytic amount of potassium acetate was used as the base.

引用

页码：883 / 885

页数：3

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