What have we learned about antinociceptive effect of botulinum toxin type A from mirror-image pain models?

被引：6

作者：

Vlah, Visnja Drinovac ^{[1
]}

Bach-Rojecky, Lidija ^{[1
]}

机构：

[1] Univ Zagreb, Dept Pharmacol, Fac Pharm & Biochem, Domagojeva 2, Zagreb 10000, Croatia

来源：

TOXICON | 2020年 / 185卷

关键词：

Botulinum neurotoxin type A; Synaptosomal-associated protein of 25 kDa; Mirror pain; Bilateral antinociceptive effect; REPEATED INTRAMUSCULAR INJECTION; RAT SPINAL MOTONEURONS; NEUROPATHIC PAIN; DORSAL-HORN; BILATERAL HYPERALGESIA; RECEPTOR EXPRESSION; AXONAL-TRANSPORT; TRPV1; EXPRESSION; SENSORY NEURONS; ACIDIC SALINE;

D O I：

10.1016/j.toxicon.2020.07.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mirror pain represents pain with complex pathophysiological background experienced at both sides of the body, usually after unilateral injury. Although observed almost 10 years ago, the phenomenon of bilateral antinociceptive effect of botulinum toxin type A (BoNT/A) following its unilateral administration in experimental mirror-image pain (MP) models remains challenging and intriguing task to explain. Data generated so far using MP models and mechanisms behind this unique feature of BoNT/A might influence the overall understanding of its mechanism of antinociceptive action. Here we review the effects contributing to BoNT/A's bilateral antinociceptive action observed in experimental MP models.

引用

页码：164 / 173

页数：10

共 13 条

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Vlah, V. Drinovac
Bach-Rojecky, L.
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JOURNAL OF NEURAL TRANSMISSION, 2016, 123 (12) : 1403 - 1413
[2] Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain
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Journal of Neural Transmission, 2016, 123 : 1403 - 1413
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[10] Characterization of the antinociceptive effect of PhTx3-4, a toxin from Phoneutria nigriventer, in models of thermal, chemical and incisional pain in mice
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