Bortezomib resistance mutations in PSMB5 determine response to second-generation proteasome inhibitors in multiple myeloma

被引:43
作者
Allmeroth, Kira [1 ]
Horn, Moritz [2 ]
Kroef, Virginia [1 ]
Miethe, Stephan [1 ]
Mueller, Roman-Ulrich [3 ,4 ,5 ,6 ]
Denzel, Martin S. [1 ,3 ,6 ]
机构
[1] Max Planck Inst Biol Ageing, Joseph Stelzmann Str 9b, D-50931 Cologne, Germany
[2] Acus Labs GmbH, Max Planck Inst Biol Ageing, Joseph Stelzmann Str 9b, D-50931 Cologne, Germany
[3] Univ Cologne, CECAD Cluster Excellence, Joseph Stelzmann Str 26, D-50931 Cologne, Germany
[4] Univ Cologne, Fac Med, Dept Internal Med 2, Kerpener Str 62, D-50937 Cologne, Germany
[5] Univ Cologne, Univ Hosp Cologne, Kerpener Str 62, D-50937 Cologne, Germany
[6] Univ Cologne, Ctr Mol Med Cologne CMMC, Robert Koch Str 21, D-50931 Cologne, Germany
关键词
20S PROTEASOME;
D O I
10.1038/s41375-020-0989-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:887 / 892
页数:6
相关论文
共 15 条
[1]   Spectrum and functional validation of PSMB5 mutations in multiple myeloma [J].
Barrio, Santiago ;
Stuehmer, Thorsten ;
Da-Via, Matteo ;
Barrio-Garcia, Clara ;
Lehners, Nicola ;
Besse, Andrej ;
Cuenca, Isabel ;
Garitano-Trojaola, Andoni ;
Fink, Severin ;
Leich, Ellen ;
Chatterjee, Manik ;
Driessen, Christoph ;
Martinez-Lopez, Joaquin ;
Rosenwald, Andreas ;
Beckmann, Roland ;
Bargou, Ralf C. ;
Braggio, Esteban ;
Stewart, A. Keith ;
Raab, Marc S. ;
Einsele, Hermann ;
Kortuem, K. Martin .
LEUKEMIA, 2019, 33 (02) :447-456
[2]   In Vitro and In Vivo Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells [J].
Chauhan, Dharminder ;
Tian, Ze ;
Zhou, Bin ;
Kuhn, Deborah ;
Orlowski, Robert ;
Raje, Noopur ;
Richardson, Paul ;
Anderson, Kenneth C. .
CLINICAL CANCER RESEARCH, 2011, 17 (16) :5311-5321
[3]   Crystal Structure of the Human 20S Proteasome in Complex with Carfilzomib [J].
Harshbarger, Wayne ;
Miller, Chase ;
Diedrich, Chandler ;
Sacchettini, James .
STRUCTURE, 2015, 23 (02) :418-424
[4]   Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets [J].
Hideshima, Teru ;
Mitsiades, Constantine ;
Tonon, Giovanni ;
Richardson, Paul G. ;
Anderson, Kenneth C. .
NATURE REVIEWS CANCER, 2007, 7 (08) :585-598
[5]  
Horn Moritz, 2018, Oncotarget, V9, P9838, DOI 10.18632/oncotarget.24305
[6]   Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myelorna [J].
Kuhn, Deborah J. ;
Chen, Qing ;
Voorhees, Peter M. ;
Strader, John S. ;
Shenk, Kevin D. ;
Sun, Congcong M. ;
Derno, Susan D. ;
Bennett, Mark K. ;
Van Leeuwen, Fijs W. B. ;
Chanan-Khan, Asher A. ;
Orlowski, Robert Z. .
BLOOD, 2007, 110 (09) :3281-3290
[7]   Clinical course of patients with relapsed multiple myeloma [J].
Kumar, SK ;
Therneau, TM ;
Gertz, MA ;
Lacy, MQ ;
Dispenzieri, A ;
Rajkumar, SV ;
Fonseca, R ;
Witzig, TE ;
Lust, JA ;
Larson, DR ;
Kyle, RA ;
Greipp, PR .
MAYO CLINIC PROCEEDINGS, 2004, 79 (07) :867-874
[8]   The resistance mechanisms of proteasome inhibitor bortezomib [J].
Lü S. ;
Wang J. .
Biomarker Research, 1 (1)
[9]   Mechanisms of proteasome inhibitor action and resistance in cancer [J].
McConkey, David J. ;
Zhu, Keyi .
DRUG RESISTANCE UPDATES, 2008, 11 (4-5) :164-179
[10]   Molecular basis of resistance to proteasome inhibitors in hematological malignancies [J].
Niewerth, Denise ;
Jansen, Gerrit ;
Assaraf, Yehuda G. ;
Zweegman, Sonja ;
Kaspers, Gertjan J. L. ;
Cloos, Jacqueline .
DRUG RESISTANCE UPDATES, 2015, 18 :18-35