Niches for Hematopoietic Stem Cells and Their Progeny

被引：297

作者：

Wei, Qiaozhi ^{[1
,2
]}

Frenette, Paul S. ^{[1
,2
,3
]}

机构：

[1] Albert Einstein Coll Med, Ruth L & David S Gottesman Inst Stem Cell & Regen, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

来源：

IMMUNITY | 2018年 / 48卷 / 04期

基金：

美国国家卫生研究院;

关键词：

COLONY-STIMULATING FACTOR; BONE-MARROW ADIPOCYTES; MESENCHYMAL STROMAL CELLS; CHEMOKINE RECEPTOR CXCR4; REGULATORY T-CELLS; NF-KAPPA-B; SELF-RENEWAL; ENDOTHELIAL-CELLS; EXTRAMEDULLARY HEMATOPOIESIS; LYMPHOID PROGENITORS;

D O I：

10.1016/j.immuni.2018.03.024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Steady-state hematopoietic stem cells' (HSCs) self-renewal and differentiation toward their mature progeny in the adult bone marrow is tightly regulated by cues from the microenvironment. Recent insights into the cellular and molecular constituents have uncovered a high level of complexity. Here, we review emerging evidence showing how HSCs and their progeny are regulated by an interdependent network of mesenchymal stromal cells, nerve fibers, the vasculature, and also other hematopoietic cells. Understanding the interaction mechanisms in these intricate niches will provide great opportunities for HSC-related therapies and immune modulation.

引用

页码：632 / 648

页数：17

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