Niches for Hematopoietic Stem Cells and Their Progeny

被引：284
|
作者：
Wei, Qiaozhi [1 ,2 ]
Frenette, Paul S. [1 ,2 ,3 ]
机构：
[1] Albert Einstein Coll Med, Ruth L & David S Gottesman Inst Stem Cell & Regen, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10461 USA
[3] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA
来源：
IMMUNITY | 2018年 / 48卷 / 04期
基金：
美国国家卫生研究院;
关键词：
COLONY-STIMULATING FACTOR; BONE-MARROW ADIPOCYTES; MESENCHYMAL STROMAL CELLS; CHEMOKINE RECEPTOR CXCR4; REGULATORY T-CELLS; NF-KAPPA-B; SELF-RENEWAL; ENDOTHELIAL-CELLS; EXTRAMEDULLARY HEMATOPOIESIS; LYMPHOID PROGENITORS;
D O I：
10.1016/j.immuni.2018.03.024
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Steady-state hematopoietic stem cells' (HSCs) self-renewal and differentiation toward their mature progeny in the adult bone marrow is tightly regulated by cues from the microenvironment. Recent insights into the cellular and molecular constituents have uncovered a high level of complexity. Here, we review emerging evidence showing how HSCs and their progeny are regulated by an interdependent network of mesenchymal stromal cells, nerve fibers, the vasculature, and also other hematopoietic cells. Understanding the interaction mechanisms in these intricate niches will provide great opportunities for HSC-related therapies and immune modulation.
引用
收藏
页码：632 / 648
页数：17
相关论文
共 50 条
  • [1] Niches of Hematopoietic Stem Cells in Bone Marrow
    Belyaysky, A., V
    MOLECULAR BIOLOGY, 2019, 53 (06) : 889 - 895
  • [2] Hematopoietic Stem cells are located in Niches normoxic
    Niemeyer, E.
    Kamoun, W. S.
    Han, H. -S
    Gillissen, M.
    Martin, J.
    Lanning, R.
    Bawendi, M. G.
    Munn, L. L.
    Fukuruma, D.
    Duda, D. G.
    Dunst, J.
    Jain, R. K.
    STRAHLENTHERAPIE UND ONKOLOGIE, 2011, 187 : 128 - 128
  • [3] Origins of blood: Hematopoietic stem cells and their niches
    Mikkola, Hanna
    EXPERIMENTAL HEMATOLOGY, 2007, 35 (09) : 16 - 16
  • [4] Bone marrow niches for hematopoietic stem cells
    Pereira, Ana Luisa
    Galli, Serena
    Nombela-Arrieta, Cesar
    HEMASPHERE, 2024, 8 (08):
  • [5] Niches of Hematopoietic Stem Cells in Bone Marrow
    A. V. Belyavsky
    Molecular Biology, 2019, 53 : 889 - 895
  • [6] The crosstalk between hematopoietic stem cells and their niches
    Durand, Charles
    Charbord, Pierre
    Jaffredo, Thierry
    CURRENT OPINION IN HEMATOLOGY, 2018, 25 (04) : 285 - 289
  • [7] Regulation of hematopoietic stem cells by their mature progeny
    de Graaf, Carolyn A.
    Kauppi, Maria
    Baldwin, Tracey
    Hyland, Craig D.
    Metcalf, Donald
    Willson, Tracy A.
    Carpinelli, Marina R.
    Smyth, Gordon K.
    Alexander, Warren S.
    Hilton, Douglas J.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (50) : 21689 - 21694
  • [8] REGULATION OF HEMATOPOIETIC STEM CELLS BY THEIR MATURE PROGENY
    de Graaf, C. A.
    Kauppi, M.
    Baldwin, T.
    Hyland, C.
    Carpinelli, M.
    Metcalf, D.
    Smyth, G. K.
    Alexander, W. S.
    Hilton, D. J.
    EXPERIMENTAL HEMATOLOGY, 2010, 38 (09) : S118 - S118
  • [9] The Regulation of Normal and Leukemic Hematopoietic Stem Cells by Niches
    Huang, Meng-meng
    Zhu, Jiang
    CANCER MICROENVIRONMENT, 2012, 5 (03) : 295 - 305
  • [10] Niches for hematopoietic stem cells and immune cell progenitors
    Sugiyama, Tatsuki
    Omatsu, Yoshiki
    Nagasawa, Takashi
    INTERNATIONAL IMMUNOLOGY, 2019, 31 (01) : 5 - 11
12345