Self-Assembled, Chitosan Grafted PLGA Nanoparticles for Intranasal Delivery: Design, Development and Ex Vivo Characterization

被引：47
|
作者：
Chalikwar, Shailesh S. [1 ]
Mene, Bhushan S. [1 ]
Pardeshi, Chandrakant V. [1 ]
Belgamwar, Veena S. [1 ]
Surana, Sanjay J. [1 ]
机构：
[1] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut & Qual Assurance, Shirpur 425405, Maharashtra, India
来源：
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING | 2013年 / 52卷 / 04期
关键词：
Chitosan; Complexation; Mucin; Mucoadhesion; PLGA; Polymer grafting; Surface modification; SOLID LIPID NANOPARTICLES; DRUG-DELIVERY; MUCOADHESIVE MICROSPHERES; FORMULATION VARIABLES; IN-VITRO; OPTIMIZATION; MICELLES; CARRIERS; SYSTEM;
D O I：
10.1080/03602559.2012.751999
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The objective of present study was to modify the surface of Poly(D,L-lactide-co-glycolide acid) (PLGA) nanoparticles (NPs) with chitosan to enhance the mucoadhesive potential of carrier system. Grafting of chitosan on PLGA surface was carried out via amide bond formation mediated by carbodiimide and confirmed by FTIR spectroscopy. Self-assembled PLGA NPs containing chlorpromazine hydrochloride were fabricated by 23 factorial design. The improved mucoadhesive potential was confirmed by several tests including in vitro mucoadhesion study. Ex vivo permeation was satisfactory. Histopathological study on sheep nasal mucosa revealed safe mucoadhesion. They were also found to be robust on accelerated stability study.
引用
收藏
页码：368 / 380
页数：13
相关论文
共 50 条
  • [31] Self-Assembled Lipid Nanoparticles for Oral Delivery of Heparin-Coated Iron Oxide Nanoparticles for Theranostic Purposes
    Truzzi, Eleonora
    Bongio, Chiara
    Sacchetti, Francesca
    Maretti, Eleonora
    Montanari, Monica
    Iannuccelli, Valentina
    Vismara, Elena
    Leo, Eliana
    MOLECULES, 2017, 22 (06)
  • [32] Biodegradable self-assembled nanoparticles of PEG-PLGA amphiphilic diblock copolymer as a promising stealth system for augmented vinpocetine brain delivery
    Ahmed, Osama A. A.
    Badr-Eldin, Shaimaa M.
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 588
  • [33] Self-assembled nanoparticles of PLGA-conjugated glucosamine as a sustained transdermal drug delivery vehicle
    Mohana Marimuthu
    Devasier Bennet
    Sanghyo Kim
    Polymer Journal, 2013, 45 : 202 - 209
  • [34] Self-assembled nanoparticles of PLGA-conjugated glucosamine as a sustained transdermal drug delivery vehicle
    Marimuthu, Mohana
    Bennet, Devasier
    Kim, Sanghyo
    POLYMER JOURNAL, 2013, 45 (02) : 202 - 209
  • [35] Self-assembled tacrolimus-loaded lecithin-chitosan hybrid nanoparticles for in vivo management of psoriasis
    Fereig, Salma A.
    El-Zaafarany, Ghada M.
    Arafa, Mona G.
    Abdel-Mottaleb, Mona M. A.
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 608
  • [36] Development of Chitosan-Coated PLGA-Based Nanoparticles for Improved Oral Olaparib Delivery: In Vitro Characterization, and In Vivo Pharmacokinetic Studies
    Anwer, Md Khalid
    Ali, Essam A.
    Iqbal, Muzaffar
    Ahmed, Mohammed Muqtader
    Aldawsari, Mohammed F.
    Al Saqr, Ahmed
    Alalaiwe, Ahmed
    Soliman, Gamal A.
    PROCESSES, 2022, 10 (07)
  • [37] Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery
    Lee, Hyukjin
    Lytton-Jean, Abigail K. R.
    Chen, Yi
    Love, Kevin T.
    Park, Angela I.
    Karagiannis, Emmanouil D.
    Sehgal, Alfica
    Querbes, William
    Zurenko, Christopher S.
    Jayaraman, Muthusamy
    Peng, Chang G.
    Charisse, Klaus
    Borodovsky, Anna
    Manoharan, Muthiah
    Donahoe, Jessica S.
    Truelove, Jessica
    Nahrendorf, Matthias
    Langer, Robert
    Anderson, Daniel G.
    NATURE NANOTECHNOLOGY, 2012, 7 (06) : 389 - 393
  • [38] Thiolated Chitosan Nanoparticles as an Oral Delivery System for Amikacin: In Vitro and Ex Vivo Evaluations
    Atyabi, F.
    Talaie, F.
    Dinarvand, R.
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2009, 9 (08) : 4593 - 4603
  • [39] Self-assembled nanoparticles based on amphiphilic chitosan derivative and hyaluronic acid for gene delivery
    Liu, Ya
    Kong, Ming
    Cheng, Xiao Jie
    Wang, Qian Qian
    Jiang, Li Ming
    Chen, Xi Guang
    CARBOHYDRATE POLYMERS, 2013, 94 (01) : 309 - 316
  • [40] Self-assembled cyclodextrin nanoparticles and drug delivery
    Thorsteinn Loftsson
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2014, 80 : 1 - 7
12345