Self-Assembled, Chitosan Grafted PLGA Nanoparticles for Intranasal Delivery: Design, Development and Ex Vivo Characterization

被引：48
作者：
Chalikwar, Shailesh S. [1 ]
Mene, Bhushan S. [1 ]
Pardeshi, Chandrakant V. [1 ]
Belgamwar, Veena S. [1 ]
Surana, Sanjay J. [1 ]
机构：
[1] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut & Qual Assurance, Shirpur 425405, Maharashtra, India
来源：
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING | 2013年 / 52卷 / 04期
关键词：
Chitosan; Complexation; Mucin; Mucoadhesion; PLGA; Polymer grafting; Surface modification; SOLID LIPID NANOPARTICLES; DRUG-DELIVERY; MUCOADHESIVE MICROSPHERES; FORMULATION VARIABLES; IN-VITRO; OPTIMIZATION; MICELLES; CARRIERS; SYSTEM;
D O I：
10.1080/03602559.2012.751999
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The objective of present study was to modify the surface of Poly(D,L-lactide-co-glycolide acid) (PLGA) nanoparticles (NPs) with chitosan to enhance the mucoadhesive potential of carrier system. Grafting of chitosan on PLGA surface was carried out via amide bond formation mediated by carbodiimide and confirmed by FTIR spectroscopy. Self-assembled PLGA NPs containing chlorpromazine hydrochloride were fabricated by 23 factorial design. The improved mucoadhesive potential was confirmed by several tests including in vitro mucoadhesion study. Ex vivo permeation was satisfactory. Histopathological study on sheep nasal mucosa revealed safe mucoadhesion. They were also found to be robust on accelerated stability study.
引用
收藏
页码：368 / 380
页数：13
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