Coordination Polymer Coated Mesoporous Silica Nanoparticles for pH-Responsive Drug Release

被引：225
|
作者：
Xing, Lei [1 ]
Zheng, Haoquan [1 ]
Cao, Yuanyuan [1 ]
Che, Shunai [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, State Key Lab Met Matrix Composites, Key Lab Thin Film & Microfabricat Technol,Minist, Shanghai 200240, Peoples R China
来源：
ADVANCED MATERIALS | 2012年 / 24卷 / 48期
关键词：
coordination bond; pH-responsive nanoparticles; mesoporous silica; coordination polymers; drug delivery; GUEST MOLECULES; DELIVERY-SYSTEM; IN-VITRO; NANOVALVES; PARTICLES; SUPPORTS; DESIGN; VALVE;
D O I：
10.1002/adma.201201742
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Coordination polymer coated mesoporous silica nanoparticles for drug delivery are successfully synthesized. The system ensures that drugs are stored in the mesopores under a physiological environment. Upon H+ stimulus in the endosomal and lysosomal compartments, the drugs are released into the intracellular organelles of cancer cells, effectively killing the cells.
引用
收藏
页码：6433 / 6437
页数：5
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