Coordination Polymer Coated Mesoporous Silica Nanoparticles for pH-Responsive Drug Release

被引：228

作者：

Xing, Lei ^{[1
]}

Zheng, Haoquan ^{[1
]}

Cao, Yuanyuan ^{[1
]}

Che, Shunai ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, State Key Lab Met Matrix Composites, Key Lab Thin Film & Microfabricat Technol,Minist, Shanghai 200240, Peoples R China

来源：

ADVANCED MATERIALS | 2012年 / 24卷 / 48期

关键词：

coordination bond; pH-responsive nanoparticles; mesoporous silica; coordination polymers; drug delivery; GUEST MOLECULES; DELIVERY-SYSTEM; IN-VITRO; NANOVALVES; PARTICLES; SUPPORTS; DESIGN; VALVE;

D O I：

10.1002/adma.201201742

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Coordination polymer coated mesoporous silica nanoparticles for drug delivery are successfully synthesized. The system ensures that drugs are stored in the mesopores under a physiological environment. Upon H+ stimulus in the endosomal and lysosomal compartments, the drugs are released into the intracellular organelles of cancer cells, effectively killing the cells.

引用

页码：6433 / 6437

页数：5

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