miR-370 is stage-specifically expressed during mouse embryonic development and regulates Dnmt3a

被引：28

作者：

Liu Qi ^{[1
]}

He Hongjuan ^{[1
]}

Gu Ning ^{[1
]}

Han Zhengbin ^{[1
]}

Xing Yanjiang ^{[1
]}

Zeng Tiebo ^{[1
]}

Huang Zhijun ^{[1
]}

Wu Qiong ^{[1
]}

机构：

[1] Harbin Inst Technol, Sch Life Sci & Biotechnol, Harbin 150001, Heilongjian, Peoples R China

来源：

FEBS LETTERS | 2013年 / 587卷 / 06期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

miR-370; Spatiotemporal expression; Embryonic development; Dnmt3a; ACUTE MYELOID-LEUKEMIA; MICRORNAS; CANCER; CELLS; DIFFERENTIATION; OVEREXPRESSION; METHYLATION; DROSOPHILA; CARCINOMA; PATTERNS;

D O I：

10.1016/j.febslet.2013.01.070

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are small non-coding RNAs that participate in a large variety of biological processes. In this paper, the spatiotemporal expression pattern of miR-370 was characterized during mouse embryonic development, and was found to be stage-and tissue-specifically expressed. In addition, through luciferase reporter assays and western blot analyses, DNA methyltransferase 3A (Dnmt3a) was identified as a directly regulated target of miR-370. Altogether, our results indicate that miR-370 may play important roles in the morphogenesis of diverse organs, especially brain and adrenal glands, by mediating Dnmt3a expression during mouse development. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：775 / 781

页数：7

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