Cu-catalyzed decarboxylative coupling of propiolic acids with boronic acids

被引：29
作者：
Shi, Leilei [1 ,2 ]
Jia, Wei [2 ]
Li, Xun [1 ]
Jiao, Ning [2 ,3 ]
机构：
[1] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, Jinan 250012, Shandong, Peoples R China
[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
[3] E China Normal Univ, Dept Chem, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 15期
基金：
美国国家科学基金会;
关键词：
Decarboxylative coupling; Propiolic acids; Boronic acids; Unsymmetrical alkynes; ALKYNYL CARBOXYLIC-ACIDS; TERMINAL ALKYNES; ARYL HALIDES; VINYL HALIDES; SONOGASHIRA REACTION; CROSS-COUPLINGS; PALLADIUM-FREE; IODIDES; HALODECARBOXYLATION; EFFICIENT;
D O I：
10.1016/j.tetlet.2013.01.118
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild procedure of Cu-catalyzed decarboxylative cross-coupling of aryl- and alkynyl-boronic acids for construction of unsymmetrical substituted alkynes has been developed. The usage of inexpensive copper chloride as catalyst, and employing stable alkynl carboxylic acids and boronic acids as the substrates under oxidative conditions for sp-sp(2) coupling, make this method very easy to operate. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1951 / 1955
页数：5
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