Chromatographic enantioseparations of binaphthyl compounds on an immobilized polysaccharide-based chiral stationary phase

被引：31

作者：

Weng, Wen ^{[1
]}

Guo, Hongxu ^{[1
]}

Zhan, Fengping ^{[1
]}

Fang, Hongli ^{[1
]}

Wang, Qingxiang ^{[1
]}

Yao, Bixia ^{[1
]}

Li, Shunxing ^{[1
]}

机构：

[1] Zhangzhou Normal Univ, Dept Chem & Environm Sci, Zhangzhou 363000, Peoples R China

来源：

JOURNAL OF CHROMATOGRAPHY A | 2008年 / 1210卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Enantiomer separation; Derivatization; LC; Binaphthyl compounds; Chiralpak IA column; Solvent effect; Thermodynamic parameters;

D O I：

10.1016/j.chroma.2008.09.048

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven binaphthyl compounds were enantioseparated by HPLC with an immobilized polysaccharide-based chiral stationary phase, Chiralpak IA. The experiments were performed under normal-phase conditions. Effects of polar modifier and column temperature on the retention time and separation factor were evaluated. All examined compounds obtained complete resolutions. This was the unique one ever reported that 1,1'-bi-2-naphthol and its monoether, diether and diester derivatives could all be enantioseparated on a given CSP. Apparent thermodynamic parameters were also deduced from Van't Hoff plots, and some aspects of chiral recognition mechanism were discussed further. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：178 / 184

页数：7

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