MAGE-A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer

被引：16

作者：

Gu, Lina ^{[1
]}

Sang, Meixiang ^{[1
,2
]}

Yin, Danjing ^{[1
]}

Liu, Fei ^{[1
]}

Wu, Yunyan ^{[1
]}

Liu, Shina ^{[1
]}

Huang, Weina ^{[1
]}

Shan, Baoen ^{[1
,2
]}

机构：

[1] Hebei Med Univ, Res Ctr, Hosp 4, 14 Jiankang Rd, Shijiazhuang 050017, Hebei, Peoples R China

[2] Hebei Med Univ, Tumor Res Inst, Hosp 4, Shijiazhuang, Hebei, Peoples R China

来源：

THORACIC CANCER | 2018年 / 9卷 / 04期

关键词：

Biological marker; lung cancer; MAGE; metastasis; prognosis; CIRCULATING TUMOR-CELLS; CLINICAL-SIGNIFICANCE; BREAST-CANCER; STATISTICS; ANTIGEN;

D O I：

10.1111/1759-7714.12571

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundMAGE-A genes belong to the cancer/testis antigens family. The prognostic significance of MAGE-A expression in the peripheral blood of patients with lung cancer is unknown. Therefore, this study evaluated the expression and possible prognostic significance of MAGE-A in the peripheral blood of patients with lung cancer. MethodsIn this study, we detected MAGE-A gene expression in the peripheral blood of 150 patients with lung cancer and 30 healthy donors using multiplex semi-nested PCR and analyzed their correlation with clinicopathological risk factors. ResultsMAGE-A expression was associated with factors indicating poor prognosis. The expression of MAGE-A and each individual MAGE-A gene were also associated with low overall survival in patients with lung cancer. ConclusionThe expression of MAGE-A genes in peripheral blood may act as a poor prognostic marker in patients with lung cancer.

引用

页码：431 / 438

页数：8

共 22 条

[21] Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and IMAGE-A12 gene promoters
Wischnewski, Frank
Friese, Olaf
Pantel, Klaus
Schwarzenbach, Heidi
[J]. MOLECULAR CANCER RESEARCH, 2007, 5 (07) : 749 - 759
[22] Zhang SY, 2015, INT J CLIN EXP PATHO, V8, P541

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