MAGE-A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer

被引：16
作者：
Gu, Lina [1 ]
Sang, Meixiang [1 ,2 ]
Yin, Danjing [1 ]
Liu, Fei [1 ]
Wu, Yunyan [1 ]
Liu, Shina [1 ]
Huang, Weina [1 ]
Shan, Baoen [1 ,2 ]
机构：
[1] Hebei Med Univ, Res Ctr, Hosp 4, 14 Jiankang Rd, Shijiazhuang 050017, Hebei, Peoples R China
[2] Hebei Med Univ, Tumor Res Inst, Hosp 4, Shijiazhuang, Hebei, Peoples R China
来源：
THORACIC CANCER | 2018年 / 9卷 / 04期
关键词：
Biological marker; lung cancer; MAGE; metastasis; prognosis; CIRCULATING TUMOR-CELLS; CLINICAL-SIGNIFICANCE; BREAST-CANCER; STATISTICS; ANTIGEN;
D O I：
10.1111/1759-7714.12571
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BackgroundMAGE-A genes belong to the cancer/testis antigens family. The prognostic significance of MAGE-A expression in the peripheral blood of patients with lung cancer is unknown. Therefore, this study evaluated the expression and possible prognostic significance of MAGE-A in the peripheral blood of patients with lung cancer. MethodsIn this study, we detected MAGE-A gene expression in the peripheral blood of 150 patients with lung cancer and 30 healthy donors using multiplex semi-nested PCR and analyzed their correlation with clinicopathological risk factors. ResultsMAGE-A expression was associated with factors indicating poor prognosis. The expression of MAGE-A and each individual MAGE-A gene were also associated with low overall survival in patients with lung cancer. ConclusionThe expression of MAGE-A genes in peripheral blood may act as a poor prognostic marker in patients with lung cancer.
引用
收藏
页码：431 / 438
页数：8
相关论文
共 22 条
  • [1] Balic M, 2012, EXPERT REV MOL DIAGN, V12, P303, DOI [10.1586/ERM.12.12, 10.1586/erm.12.12]
  • [2] Cancer Statistics in China, 2015
    Chen, Wanqing
    Zheng, Rongshou
    Baade, Peter D.
    Zhang, Siwei
    Zeng, Hongmei
    Bray, Freddie
    Jemal, Ahmedin
    Yu, Xue Qin
    He, Jie
    [J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2016, 66 (02) : 115 - 132
  • [3] Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells
    Fehm, Tanja
    Hoffmann, Oliver
    Aktas, Bahriye
    Becker, Sven
    Solomayer, Erich F.
    Wallwiener, Diethelm
    Kimmig, Rainer
    Kasimir-Bauer, Sabine
    [J]. BREAST CANCER RESEARCH, 2009, 11 (04):
  • [4] The expression and clinical significance of melanoma-associated antigen-A1,-A3 and-A11 in glioma
    Guo, Liru
    Sang, Meixiang
    Liu, Qingrui
    Fan, Xiaojie
    Zhang, Xiao
    Shan, Baoen
    [J]. ONCOLOGY LETTERS, 2013, 6 (01) : 55 - 62
  • [5] Expressions of MAGE-A9 and MAGE-A11 in Breast Cancer and their Expression Mechanism
    Hou, Shu-yun
    Sang, Mei-xiang
    Geng, Cui-zhi
    Liu, Wei-hua
    Lu, Wei-hua
    Xu, Ying-ying
    Shan, Bao-en
    [J]. ARCHIVES OF MEDICAL RESEARCH, 2014, 45 (01) : 44 - 51
  • [6] Prognostic value of circulating tumor cells with podoplanin expression in patients with locally advanced or metastatic head and neck squamous cell carcinoma
    Hsieh, Jason Chia-Hsun
    Lin, Hung-Chih
    Huang, Chi-Ya
    Hsu, Hsung-Ling
    Wu, Tyler Min-Hsien
    Lee, Chia-Lin
    Chen, Min-Chi
    Wang, Hung-Ming
    Tseng, Ching-Ping
    [J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2015, 37 (10): : 1448 - 1455
  • [7] Circulating Tumor Cells in Breast Cancer: Detection Systems, Molecular Characterization, and Future Challenges
    Lianidou, Evi S.
    Markou, Athina
    [J]. CLINICAL CHEMISTRY, 2011, 57 (09) : 1242 - 1255
  • [8] Expression of MAGE-A1, -A9, -A11 in laryngeal squamous cell carcinoma and their prognostic significance: a retrospective clinical study
    Liu, Shenghui
    Sang, Meixiang
    Xu, Yuru
    Gu, Lina
    Liu, Fei
    Shan, Baoen
    [J]. ACTA OTO-LARYNGOLOGICA, 2016, 136 (05) : 506 - 513
  • [9] Prognostic role of circulating tumor cells and disseminated tumor cells in patients with prostate cancer: a systematic review and meta-analysis
    Ma, Xuelei
    Xiao, Zhilan
    Li, Xiaojun
    Wang, Fengtian
    Zhang, Jing
    Zhou, Rubai
    Wang, Junbo
    Liu, Lei
    [J]. TUMOR BIOLOGY, 2014, 35 (06) : 5551 - 5560
  • [10] Clinical Significance of Circulating Tumor Cells in Peripheral Blood of Patients with Esophageal Squamous Cell Carcinoma
    Matsushita, Daisuke
    Uenosono, Yoshikazu
    Arigami, Takaaki
    Yanagita, Shigehiro
    Nishizono, Yuka
    Hagihara, Takahiko
    Hirata, Munetsugu
    Haraguchi, Naoto
    Arima, Hideo
    Kijima, Yuko
    Kurahara, Hiroshi
    Maemura, Kosei
    Okumura, Hiroshi
    Ishigami, Sumiya
    Natsugoe, Shoji
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2015, 22 (11) : 3674 - 3680
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