Effect of lysophosphatidic acid on the ovum transport in mouse oviducts

被引：36
作者：
Kunikata, K
Yamano, S
Tokumura, A
Aono, T
机构：
[1] Univ Tokushima, Sch Med, Dept Obstet & Gynecol, Tokushima 7708503, Japan
[2] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan
来源：
LIFE SCIENCES | 1999年 / 65卷 / 08期
关键词：
ovum transport; lysophosphatidic acid; pertussis toxin; verapamil; mouse;
D O I：
10.1016/S0024-3205(99)00310-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of lysophosphatidic acid (LPA) on ovum transport in mouse oviducts were studied. When excised oviducts were incubated at 37 degrees C under 5% CO2 in humidified air for 24 hours, addition of LPA at 10 mu M to the medium significantly accelerated the rate of ovum transport, and 1 mu M LPA slightly increased the ovum transport rate, These increases were not inhibited by 10 mu M indomethacin, a cyclooxygense inhibitor, but were suppressed by 200 ng/ml of pertussis toxin or 10 mu M verapamil, a voltage-sensitive calcium channel blocker. These data suggested that LPA stimulates mouse ovum transport by contracting oviductual smooth muscle via a voltage-sensitive calcium channel mediated by a pertussis toxin-sensitive G-protein-linked receptor.
引用
收藏
页码：833 / 840
页数：8
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