Optimization of glycerol feeding for clavulanic acid production by Streptomyces clavuligerus with glycerol feeding

被引：35
|
作者：
Chen, KC [1 ]
Lin, YH
Tsai, CM
Hsieh, CH
Houng, JY
机构：
[1] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu, Taiwan
[2] I Shou Univ, Dept Chem Engn, Kaohsiung, Taiwan
来源：
BIOTECHNOLOGY LETTERS | 2002年 / 24卷 / 06期
关键词：
clavulanic acid; feeding; glycerol; Streptomyces clavuligerus;
D O I：
10.1023/A:1014553109425
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Glycerol at 10-20 g l(-1) increased clavulanic acid production by Streptomyces clavuligerus in shake-flask culture. The biosynthesis of clavulanic acid continued for longer by feeding glycerol and production increased to 250 mg l(-1) compared with 115 mg l(-1) without feeding. In fermenter batch culture, degradation of clavulanic acid began after 72 h. With glycerol feeding in fed-batch culture, clavulanic acid production was not only increased further to about 280 mg l(-1) but also remained stable up to 130 h.
引用
收藏
页码：455 / 458
页数：4
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