Palladium-Catalyzed C-H Arylation of Amides by Triazole Assistance

被引：33

作者：

Santrac, Darko ^{[1
]}

Cella, Stefano ^{[1
]}

Wang, Wei ^{[1
]}

Ackermann, Lutz ^{[1
]}

机构：

[1] Georg August Univ, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 2016卷 / 32期

基金：

欧洲研究理事会;

关键词：

Synthetic methods; C-H activation; Amides; Palladium; Arenes; UNACTIVATED C(SP(3))-H BONDS; BENZOIC-ACID DERIVATIVES; DIRECTING GROUP; 1,2,3-TRIAZOLE AMINE; C(SP(2))-H BONDS; AROMATIC AMIDES; CLICK CHEMISTRY; ACTIVATION; ALKYLATION; SP(3);

D O I：

10.1002/ejoc.201601045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Versatile palladium-catalyzed C-H arylations of benzamides were accomplished with the assistance of a removable triazole amine (TAM). The robustness of the palladium-catalyzed C-H functionalization protocol is reflected in its broad functional group tolerance, ample substrate scope, and ability to proceed under silver-free reaction conditions.

引用

页码：5429 / 5436

页数：8

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