Circulation of enterovirus D68 (EV-D68) causing respiratory illness in New South Wales, Australia, between August 2018 and November 2019

被引：4

作者：

Stelzer-Braid, Sacha ^{[1
,2
,21
]}

Yeang, Malinna ^{[1
]}

Britton, Philip N. ^{[3
,4
]}

Kim, Ki Wook ^{[1
,5
]}

Varadhan, Hemalatha ^{[6
]}

Andrews, Peter Ian ^{[5
,7
]}

Briest, Romain ^{[7
]}

Branley, James ^{[8
,9
]}

Balgahom, Rifky ^{[8
]}

Burrell, Rebecca ^{[4
]}

Gehrig, Nicole ^{[6
]}

Newcombe, James ^{[10
]}

Kesson, Alison ^{[3
,9
]}

Kok, Jen ^{[11
]}

Maley, Michael ^{[12
,13
]}

Van Hal, Sebastiaan ^{[9
,14
]}

Macintyre, C. Raina ^{[15
,16
,17
]}

Craig, Maria E. ^{[1
,5
]}

Ferson, Mark J. ^{[18
,19
]}

Rawlinson, William D. ^{[1
,2
,5
,20
]}

机构：

[1] Prince Wales Hosp, Serol & Virol Div SAViD, Virol Res Lab, NSW Hlth Pathol, Randwick, NSW, Australia

[2] Univ New South Wales, Fac Med, Sch Med Sci, Kensington, NSW, Australia

[3] Childrens Hosp Westmead, Dept Infect Dis & Microbiol, Westmead, NSW, Australia

[4] Univ Sydney, Marie Bashir Inst, Sydney, NSW, Australia

[5] Univ New South Wales Med, Sch Womens & Childrens Hlth, Kensington, NSW, Australia

[6] John Hunter Hosp, NSW Hlth Pathol, Newcastle, NSW, Australia

[7] Sydney Childrens Hosp, Dept Neurol, Westmead, NSW, Australia

[8] Nepean Hosp, Dept Microbiol & Infect Dis, Kingswood, NSW, Australia

[9] Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia

[10] Royal North Shore Hosp, NSW Hlth Pathol, St Leonards, NSW, Australia

[11] Westmead Hosp, NSW Hlth Pathol, Westmead, NSW, Australia

[12] NSW Hlth Pathol South, Liverpool, NSW, Australia

[13] Univ New South Wales, South Western Sydney Clin Sch, Liverpool, NSW, Australia

[14] Royal Prince Alfred Hosp, Camperdown, NSW, Australia

[15] Univ New South Wales, Biosecur Program, Kirby Inst, Kensington, NSW, Australia

[16] Arizona State Univ, Coll Hlth Solut, Phoenix, AZ USA

[17] Arizona State Univ, Biodesign Inst, Ctr Environm Hlth Engn, Tempe, AZ USA

[18] South Eastern Sydney Local Hlth Dist, Publ Hlth Unit, Randwick, NSW, Australia

[19] Univ New South Wales, Sch Populat Hlth, Kensington, NSW, Australia

[20] Prince Wales Hosp, Dept Microbiol, Serol & Virol Div SAViD, NSW Hlth Pathol East, Randwick, NSW, Australia

[21] Prince Wales Hosp, Virol Res Lab, Level 3 Clin Sci Bldg, Randwick, NSW 2031, Australia

来源：

PATHOLOGY | 2022年 / 54卷 / 06期

基金：

英国医学研究理事会;

关键词：

Human enterovirus; enterovirus infections; viral meningitis; high-throughput nucleotide sequencing; ACUTE FLACCID MYELITIS; ALIGNMENT;

D O I：

10.1016/j.pathol.2022.03.007

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The incidence of enterovirus D68 (EV-D68) in New South Wales, Australia, is unknown. As part of a state-wide sur-veillance program, enterovirus positive diagnostic speci-mens were assessed from patients presenting to hospitals with respiratory and meningitis syndromes from August 2018 to November 2019. Diagnostic enterovirus positive samples were collected from 339 patients and re-extracted followed by targeted PCR across the whole EV-D68 genome (7.4 kb). Obtained amplicons (n=208) were sequenced using Illumina sequencing technology and the phylogenetic relationships analysed relative to EV-D68 Fermon strain. We identified EV-D68 in 31 patients, both children (n=27) and adults (n=4). Phylogenetically, the majority (n=30) were from subclade B3, the same as that causing out-breaks of EV-D68 across the USA and Europe during 2018. These data strengthen the importance of having an active enterovirus surveillance network.

引用

页码：784 / 789

页数：6

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