Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity

被引:87
作者
Michal, M. [1 ,2 ]
Hes, O. [2 ]
Nemcova, J. [2 ]
Sima, R. [2 ]
Kuroda, N. [4 ]
Bulimbasic, S. [6 ]
Franco, M. [7 ]
Sakaida, N. [5 ]
Danis, D. [8 ]
Kazakov, D. V. [2 ]
Ohe, C. [5 ]
Hora, M. [3 ]
机构
[1] Charles Univ Prague, Lab Spec Diagnost Med Fac Hosp, Sikls Dept Pathol, Plzen 30460, Czech Republic
[2] Charles Univ Prague, Fac Hosp, Dept Pathol, Plzen 30460, Czech Republic
[3] Charles Univ Prague, Fac Hosp, Dept Urol, Plzen 30460, Czech Republic
[4] Red Cross Hosp Kochi, Kochi, Japan
[5] Kansai Med Univ, Hirakata Hosp, Dept Pathol, Osaka, Japan
[6] Univ Zagreb, Univ Hosp Dubrava, Zagreb, Croatia
[7] EPM UNIFESP, Sao Paulo, Brazil
[8] Cytopathos SRO, Bratislava, Slovakia
关键词
Renal angiomyoadenomatous tumor; Mixed epithelial and stromal tumor; Leiomyomatous stroma; Kidney; CARBONIC-ANHYDRASE-IX; CELL CARCINOMA; STROMAL TUMOR; DIFFERENTIAL-DIAGNOSIS; KIDNEY; ANTIBODIES;
D O I
10.1007/s00428-008-0697-3
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
We present a series of a distinct tumorous entity named renal angiomyoadenomatous tumor (RAT). Five cases were retrieved from the consultation files of the authors. Histologic and immunohistochemical features were evaluated. Sequencing analysis of coding region of the VHL gene was carried out in all cases. The tumors were composed of admixture of an epithelial clear cell component and prominent leiomyomatous stroma. Epithelial cells formed adenomatous tubular formations endowed with blister-like apical snouts. All tubular/glandular structures were lined by a fine capillary network. The epithelial component was positive for epithelial membrane antigen, CK7, CK20, AE1-AE3, CAM5.2, and vimentin in all cases. In all analyzed samples, no mutation of the VHL gene was found. RAT is a distinct morphologic entity, being different morphologically, immunohistochemically, and genetically from all renal tumors including conventional clear cell carcinoma and mixed epithelial and stromal tumor of kidney.
引用
收藏
页码:89 / 99
页数:11
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