Renal toxicities of chemotherapy

被引：42

作者：

de Jonge, MJA ^{[1
]}

Verweij, J ^{[1
]}

机构：

[1] Erasmus Univ, Med Ctr, Dr Daniel den Hoed Canc Ctr, Dept Med Oncol, NL-3075 EA Rotterdam, Netherlands

来源：

SEMINARS IN ONCOLOGY | 2006年 / 33卷 / 01期

关键词：

D O I：

10.1053/j.seminoncol.2005.11.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemotherapeutic agents can produce a variety of acute and chronic organ toxicities. Since many antitumor drugs and their metabolites are cleared renally, the kidneys are vulnerable to injury. The drugs involved will determine the site of injury within the kidney, resulting in clinical manifestations ranging from an asymptomatic rise in serum creatinine to acute renal failure. The most common renal toxicities of chemotherapeutic agents are described. © 2006 Elsevier Inc. All rights reserved.

引用

页码：68 / 73

页数：6

共 54 条

[1]

AAMDAL S, 1984, J NATL CANCER I, V73, P743

[2] METHOTREXATE-INDUCED RENAL IMPAIRMENT - CLINICAL-STUDIES AND RESCUE FROM SYSTEMIC TOXICITY WITH HIGH-DOSE LEUCOVORIN AND THYMIDINE [J].