Access to cyano-substituted pyrazolines through copper-catalyzed cascade cyanation/cyclization of unactivated olefins

被引：15
|
作者：
Meng, Fei [1 ,2 ]
Fang, Qin [1 ,2 ]
Yuan, Weidong [1 ,2 ]
Xu, Ning [1 ,2 ]
Cao, Shujun [1 ,2 ]
Chun, Jianlin [1 ,2 ]
Li, Jie [1 ,2 ]
Zhang, Honglin [1 ,2 ]
Zhu, Yingguang [1 ,2 ]
机构：
[1] Nanjing Agr Univ, Jiangsu Key Lab Pesticide Sci, Coll Sci, Nanjing 210095, Peoples R China
[2] Nanjing Agr Univ, Dept Chem, Coll Sci, Nanjing 210095, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2020年 / 7卷 / 11期
基金：
中国国家自然科学基金;
关键词：
C-H CYANATION; N-RADICAL CASCADE; INTRAMOLECULAR AMINOCYANATION; OXIDATIVE CYANATION; ALKENES SYNTHESIS; BOND FORMATION; ARENES; DIFUNCTIONALIZATION; DIAMINATION; PALLADIUM;
D O I：
10.1039/d0qo00282h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and efficient copper-catalyzed domino cyanation/cyclization of hydrazone-tethered unactivated olefins has been developed. A range of cyano-containing pyrazolines have been easily obtained in good yields under mild conditions. This method provides a facile, practical, and rapid access to valuable pyrazolines with the important cyano functionality, and it is amenable for gram scale synthesis. The simultaneous formation of C(sp(3))-CN and C-N bonds can be achieved in a single step.
引用
收藏
页码：1358 / 1364
页数：7
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