Access to cyano-substituted pyrazolines through copper-catalyzed cascade cyanation/cyclization of unactivated olefins

被引：15

作者：

Meng, Fei ^{[1
,2
]}

Fang, Qin ^{[1
,2
]}

Yuan, Weidong ^{[1
,2
]}

Xu, Ning ^{[1
,2
]}

Cao, Shujun ^{[1
,2
]}

Chun, Jianlin ^{[1
,2
]}

Li, Jie ^{[1
,2
]}

Zhang, Honglin ^{[1
,2
]}

Zhu, Yingguang ^{[1
,2
]}

机构：

[1] Nanjing Agr Univ, Jiangsu Key Lab Pesticide Sci, Coll Sci, Nanjing 210095, Peoples R China

[2] Nanjing Agr Univ, Dept Chem, Coll Sci, Nanjing 210095, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2020年 / 7卷 / 11期

基金：

中国国家自然科学基金;

关键词：

C-H CYANATION; N-RADICAL CASCADE; INTRAMOLECULAR AMINOCYANATION; OXIDATIVE CYANATION; ALKENES SYNTHESIS; BOND FORMATION; ARENES; DIFUNCTIONALIZATION; DIAMINATION; PALLADIUM;

D O I：

10.1039/d0qo00282h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient copper-catalyzed domino cyanation/cyclization of hydrazone-tethered unactivated olefins has been developed. A range of cyano-containing pyrazolines have been easily obtained in good yields under mild conditions. This method provides a facile, practical, and rapid access to valuable pyrazolines with the important cyano functionality, and it is amenable for gram scale synthesis. The simultaneous formation of C(sp(3))-CN and C-N bonds can be achieved in a single step.

引用

页码：1358 / 1364

页数：7

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