Antimutagenic and antioxidant activity of Lisosan G in Saccharomyces cerevisiae

被引：27
作者：
Frassinetti, Stefania [1 ]
Della Croce, Clara Maria [1 ]
Caltavuturo, Leonardo [1 ]
Longo, Vincenzo [1 ]
机构：
[1] CNR, Inst Biol & Agr Biotechnol IBBA, Pisa Unit, Res Area Pisa, I-56124 Pisa, Italy
来源：
FOOD CHEMISTRY | 2012年 / 135卷 / 03期
关键词：
Lisosan G; Genotoxicity; Saccharomyces cerevisiae; Oxidative stress; ORAC; WHOLE-GRAIN; YEAST; CANCER; BRAN; ACID;
D O I：
10.1016/j.foodchem.2012.06.090
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In the present study the antimutagenic and antioxidant effects of a powder of grain (Lisosan G) in yeast Saccharomyces cerevisiae were studied. Results showed that Lisosan G treatment decreased significantly the intracellular ROS concentration and mutagenesis induced by hydrogen peroxide in S. cerevisiae D7 strain. The effect of Lisosan G was then evaluated by using superoxide dismutase (SOD) proficient and deficient strains of S. cerevisiae. Lisosan G showed protective activity in sod1 Delta and sod2 Delta mutant strains, indicating an in vivo antioxidant effect. A high radical scavenging activity of Lisosan G was also demonstrated in vitro using the oxygen radical absorbance capacity (ORAC) assay. The obtained results showed a protective effect of Lisosan G in yeast cells, indicating that its antioxidant capacity contributes to its antimutagenic action. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2029 / 2034
页数：6
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