Transfusion packages for massively bleeding patients:: The effect on clot formation and stability as evaluated by Thrombelastograph (TEG®)

被引：24
作者：
Johansson, Paer I. [1 ]
Bochsen, Louise [1 ]
Stensballe, Jakob [1 ]
Secher, Niels H. [2 ]
机构：
[1] Univ Copenhagen, Dept Clin Immunol, Transfus Serv, Rigshosp 2034, DK-2100 Copenhagen, Denmark
[2] Univ Copenhagen, Rigshosp, Dept Anaesthesiol, DK-2100 Copenhagen, Denmark
来源：
TRANSFUSION AND APHERESIS SCIENCE | 2008年 / 39卷 / 01期
关键词：
massive bleeding; transfusion package; haemostasis; TEG (R);
D O I：
10.1016/j.transci.2008.05.012
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We investigated the effect of administering a transfusion package encompassing 5 red blood cells (RBC), 5 fresh frozen plasma (FFP), and 2 platelet concentrates (PC) on clot formation and stability as evaluated by Thrombelastograph (TEG(R)) in 10 patients presenting with massive bleeding. Blood was obtained before and after administering the transfusion packages. Six patients were hypocoagulable before administration of the transfusion package, whereas none of the patients were hypocoagulable after transfusion of up to 7 transfusion packages (p = 0.01). In 8 patients damage control surgery was successful and 6 of these patients survived. The result indicates that an early balanced transfusion strategy maintains haemostatic competence in massively bleeding patients. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3 / 8
页数：6
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