The human vitreous humour (VH) is a transparent, highly hydrated gel, which occupies the posterior segment of the eye between the lens and the retina. Physiological and pathological conditions of the retina are reflected in the protein composition of the VH, which can be sampled as part of routine surgical procedures. Historically, many studies have investigated levels of individual proteins in VH from healthy and diseased eyes. In the last decade, proteomics analyses have been performed to characterise the proteome of the human VH and explore networks of functionally related proteins, providing insight into the aetiology of diabetic retinopathy and proliferative vitreoretinopathy. Recent proteomic studies on the VH from animal models of autoimmune uveitis have identified new signalling pathways associated to autoimmune triggers and intravitreal inflammation. This paper aims to guide biological scientists through the different proteomic techniques that have been used to analyse the VH and present future perspectives for the study of intravitreal inflammation using proteomic analyses.
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Tokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, JapanTokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, Japan
Komatsu, Hiroyuki
Usui, Yoshihiko
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Tokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, JapanTokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, Japan
Usui, Yoshihiko
Tsubota, Kinya
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Tokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, JapanTokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, Japan
Tsubota, Kinya
Fujii, Risa
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Japanese Fdn Canc Res, Canc Precis Med Ctr, Project Realizat Personalized Canc Med, Tokyo 1358550, JapanTokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, Japan
Fujii, Risa
Yamaguchi, Takefumi
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Ichikawa Gen Hosp, Dept Ophthalmol, Tokyo Dent Coll, Chiba 2728513, JapanTokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, Japan
Yamaguchi, Takefumi
Maruyama, Kazuichi
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Osaka Univ, Dept Ophthalmol, Grad Sch Med, Osaka 5650871, JapanTokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, Japan
Maruyama, Kazuichi
Wakita, Ryo
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Tokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, JapanTokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, Japan
Wakita, Ryo
Asakage, Masaki
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Tokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, JapanTokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, Japan
Asakage, Masaki
Shimizu, Hiroyuki
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Tokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, JapanTokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, Japan
Shimizu, Hiroyuki
Yamakawa, Naoyuki
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Tokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, JapanTokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, Japan
Yamakawa, Naoyuki
Nezu, Naoya
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Tokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, JapanTokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, Japan
Nezu, Naoya
Ueda, Koji
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Japanese Fdn Canc Res, Canc Precis Med Ctr, Project Realizat Personalized Canc Med, Tokyo 1358550, JapanTokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, Japan
Ueda, Koji
Goto, Hiroshi
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Tokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, JapanTokyo Med Univ, Dept Ophthalmol, Tokyo 1608402, Japan