Recent updates on incubation of drug craving: a mini-review

被引:60
|
作者
Li, Xuan [1 ]
Caprioli, Daniele [1 ]
Marchant, Nathan J. [1 ,2 ]
机构
[1] NIDA, Behav Neurosci Res Branch, Intramural Res Program, NIH,DHHS, Baltimore, MD 21224 USA
[2] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic 3010, Australia
基金
英国医学研究理事会;
关键词
Addiction; cocaine; dopamine; glutamate; incubation; relapse; COCAINE-SEEKING BEHAVIOR; TIME-DEPENDENT CHANGES; ENVIRONMENTAL ENRICHMENT; INDUCED REINSTATEMENT; EXTINCTION BEHAVIOR; NUCLEUS-ACCUMBENS; RATS; ABSTINENCE; WITHDRAWAL; STRESS;
D O I
10.1111/adb.12205
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cue-induced drug craving progressively increases after prolonged withdrawal from drug self-administration in laboratory animals, a behavioral phenomenon termed incubation of drug craving.' Studies over the years have revealed several important neural mechanisms contributing to incubation of drug craving. In this mini-review, we first discuss three excellent AddictionBiology publications on incubation of drug craving in both human and laboratory animals. We then review several key publications from the past year on behavioral and mechanistic findings related to incubation of drug craving.
引用
收藏
页码:872 / 876
页数:5
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