A novel asymmetric synthesis of cinacalcet hydrochloride

被引：17
|
作者：
Arava, Veera R. [1 ]
Gorentla, Laxminarasimhulu [1 ]
Dubey, Pramod K. [2 ]
机构：
[1] Suven Life Sci Ltd, R&D Lab, Hyderabad, Andhra Pradesh, India
[2] JNT Univ, Dept Chem, Hyderabad, Andhra Pradesh, India
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 8卷
关键词：
asymmetric synthesis; (R)-tert-butanesulfinamide; cinacalcet hydrochloride; naphthyl ethyl sulfinamide; regioselective N-alkylation; CALCIMIMETIC AGENT; REDUCTION; AMINES;
D O I：
10.3762/bjoc.8.158
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel route to asymmetric synthesis of cinacalcet hydrochloride by the application of (R)-tert-butanesulfinamide and regioselective N-alkylation of the naphthyl ethyl sulfinamide intermediate is described.
引用
收藏
页码：1366 / 1373
页数：8
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