Influence of a neoglycolipid and its PEO-lipid moiety on the organization of phospholipid monolayers

被引:15
作者
Dynarowicz-Latka, P
Rosilio, V
Boullanger, P
Fontaine, P
Goldmann, M
Baszkin, A
机构
[1] Univ Paris Sud, CNRS, UMR 8612, F-92296 Chatenay Malabry, France
[2] Jagiellonian Univ, Fac Chem, PL-30600 Krakow, Poland
[3] Univ Lyon 1, CPE Lyon, CNRS, UMR 5181, F-69622 Villeurbanne, France
[4] INSP, UMR 7588, F-75015 Paris, France
[5] LURE, F-91898 Orsay, France
关键词
D O I
10.1021/la051749w
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The surface properties of the neoglycolipid (GlcNAcE(3)G(28)) and of its PEO-lipid (E(3)G(28)) moiety mixed with phospholipids (dipalmitoylphosphatidylcholine, DPPC; distearoylphosphatidylcholine, DSPC; diarachidoylphosphatidylcholine, DAPC; and dibehenoylphosphatidylcholine, DBPC) were studied in Langmuir monolayers at various mixture compositions and surface pressures. The pi-A isotherms of the pure compounds revealed that because of the presence of the sugar group in its molecule, GlcNAcE3G28 collapsed at a higher surface pressure and occupied a larger molecular area than the PEO-lipid moiety. It was also observed that the presence of the PEO-lipid (E3G28) in the mixtures triggered a strong alteration of both phospholipid pi-A isotherm profiles and surface diffraction spectra, an indication that the disordering of the initially structured phospholipid monolayers took place. Unlike E3G28, GlcNAcE(3)G(28) did not disorganize phospholipid monolayers but generated a partial segregation of the film-forming components. The calculated excess free energies of mixing (Delta G(exc)) for GlcNAcE(3)G(28)-phospholipid mixtures enabled us to predict the stability of such systems.
引用
收藏
页码:11941 / 11948
页数:8
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