Association between follicle-stimulating hormone receptor polymorphisms and reproductive parameters in young men from the general population

被引:24
作者
Lindgren, Ida [1 ]
Giwercman, Aleksander [2 ]
Axelsson, Jonatan [2 ,3 ]
Giwercman, Yvonne Lundberg [1 ]
机构
[1] Lund Univ, Fac Med, Dept Clin Sci, SE-22185 Malmo, Sweden
[2] Skane Univ Hosp, Reprod Med Ctr, Malmo, Sweden
[3] Lund Univ, Div Occupat & Environm Med, Lund, Sweden
关键词
follicle-stimulating hormone receptor; polymorphism; sperm; SINGLE NUCLEOTIDE POLYMORPHISM; PREMATURE OVARIAN FAILURE; FSH RECEPTOR; INFERTILE MEN; LUTEINIZING-HORMONE; MOLECULAR-CLONING; IDENTIFICATION; MUTATION; TESTOSTERONE; EXPRESSION;
D O I
10.1097/FPC.0b013e3283566c42
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Objective Follicle-stimulating hormone (FSH) regulates gametogenesis through binding to its receptor (FSHR). In women, the Thr307Ala and Asn680Ser polymorphisms in the FSHR gene affect reproductive function, but it is not clear whether they have any impact on spermatogenesis and have mainly been investigated in infertile men of varying ages. The aim of the present study was therefore to examine whether these genetic variants of the FSHR influence reproductive parameters in men from the general population. Methods Men aged 17-20 years (n=313) were genotyped. All men provided a semen sample and a blood sample for hormonal measurements and DNA extraction. They underwent a medical examination and analyses of possible associations between Thr307Ala and Asn680Ser polymorphisms and hormonal and sperm parameters were subsequently carried out. Results Men homozygous for Thr307/Asn680 had a lower mean serum FSH concentration (3.07 vs. 3.65 IU/l, P = 0.009), and higher mean serum estradiol (94.0 vs. 86.1 pmol/l, P = 0.001), sex hormone-binding globulin (33.6 vs. 31.3 nmol/l, P < 0.0001), and total testosterone (19.1 vs. 17.9 nmol/l, P < 0.0001) concentrations compared with men with other genotypes. In addition, sperm concentrations (71.9 x 10(6) vs. 70.8 x 10(6) /ml, P = 0.040) and the total sperm counts were higher (212 x 10(6) vs. 206 x 10(6), P<0.0001) and their testes volumes were larger (left: 11.5 vs. 11.0 ml, P<0.0001; right: 12.4 vs. 11.6 ml, P=0.002). Conclusion As in women, the results from the present study indicate that variants of the FSHR influence reproductive parameters in men. Pharmacogenetics and Genomics 22: 667-672 (C) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins. Pharmacogenetics and Genomics 2012, 22: 667-672
引用
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页码:667 / 672
页数:6
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