Decidual Stromal Cells as Regulators of T-Cell Access to the Maternal-Fetal Interface

被引:14
作者
Silasi, Michelle [1 ]
Mor, Gil [1 ]
机构
[1] Yale Univ, Sch Med, Reprod Immunol Unit, Dept Obstet Gynecol & Reprod Sci, New Haven, CT 06520 USA
关键词
Chemokines; decidual; macrophages; pregnancy; T cells; tolerance; trophoblast; TRIMESTER TROPHOBLAST CELLS; UTERINE NK CELLS; IMMUNE-SYSTEM; PREGNANCY; IMPLANTATION; INFLAMMATION;
D O I
10.1111/aji.12006
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A recent study in the journal Science offers insights into the mechanism behind feto-maternal tolerance, as evidenced by changes in the immuno-logical environment of the uterus and decidua. They also provide a rich area of research for the understanding of the regulation of the immune system in other complicated medical conditions, including cancer and pregnancies affected by infection or autoimmunity.
引用
收藏
页码:279 / 281
页数:3
相关论文
共 14 条
[1]   First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis [J].
Abrahams, VM ;
Straszewski-Chavez, SL ;
Guller, S ;
Mor, G .
MOLECULAR HUMAN REPRODUCTION, 2004, 10 (01) :55-63
[2]   Uterine NK Cells, Spiral Artery Modification and the Regulation of Blood Pressure During Mouse Pregnancy [J].
Burke, Suzanne D. ;
Barrette, Valerie F. ;
Gravel, Jonathan ;
Carter, Alexandra L. I. ;
Hatta, Kota ;
Zhang, Jianhong ;
Chen, Zhilin ;
Leno-Duran, Ester ;
Bianco, Juares ;
Leonard, Sean ;
Murrant, Coral ;
Adams, Michael A. ;
Croy, B. Anne .
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2010, 63 (06) :472-481
[3]   Placental Viral Infection Sensitizes to Endotoxin-Induced Pre-Term Labor: A Double Hit Hypothesis [J].
Cardenas, Ingrid ;
Mor, Gil ;
Aldo, Paulomi ;
Lang, Sabine M. ;
Stabach, Paul ;
Sharp, Andrew ;
Romero, Roberto ;
Mazaki-Tovi, Shali ;
Gervasi, MariaTeresa ;
Means, Robert E. .
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2011, 65 (02) :110-117
[4]   Inflammation and Implantation [J].
Dekel, Nava ;
Gnainsky, Yulia ;
Granot, Irit ;
Mor, Gil .
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2010, 63 (01) :17-21
[5]   Regulatory T Cells and Their Role in Pregnancy [J].
Leber, Anne ;
Teles, Ana ;
Zenclussen, Ana C. .
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2010, 63 (06) :445-459
[6]   The Unique Properties of Uterine NK Cells [J].
Manaster, Irit ;
Mandelboim, Ofer .
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2010, 63 (06) :434-444
[7]  
Medawar P, 1952, S SOC EXP BIOL, V7, P320
[8]  
MEDAWAR PB, 1948, BRIT J EXP PATHOL, V29, P58
[9]   Inflammation and pregnancy: the role of the immune system at the implantation site [J].
Mor, Gil ;
Cardenas, Ingrid ;
Abrahams, Vikki ;
Guller, Seth .
REPRODUCTIVE SCIENCE, 2011, 1221 :80-87
[10]   The Immune System in Pregnancy: A Unique Complexity [J].
Mor, Gil ;
Cardenas, Ingrid .
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2010, 63 (06) :425-433