Brain tumors are the second most common malignancy and the major cause of cancer related mortality in children. Though significant advances in neuroimaging, neurosurgery, radiation therapy and chemotherapy have evolved over the years, overall survival rate remains less than 75%. Malignant gliomas, high risk medulloblastoma with recurrence and infant brain tumors continue to be a major cause of therapeutic frustration. Even today diffuse pontine gliomas are universally fatal. Though tumors like low grade glioma have an overall excellent survival, recurrences and progression in eloquent areas pose therapeutic challenges. As research continues to unravel the biology including key molecules and signaling pathways responsible for the oncogenesis of different childhood brain tumors, novel targeted therapies are profiled. Identification of major targets like the Epidermal Growth factor Receptor (EGFR), Platelet Derived Growth Factor Receptor (PDGFR), Vascular Endothelial Growth factor (VEGF) and key signaling pathways like the MAPK and PI3K/Akt/mTOR has enabled us over the recent years to better understand tumor behavior and design tailored therapy. These efforts have improved overall survival of children with brain tumors. This review article discusses the current status of common brain tumors in children and the newer therapeutic approaches.
机构:
Hosp San Juan Dios, Dept Pediat Hematol & Oncol, Pediat Neurooncol, Passeig St Joan de Deu 2, Barcelona 08950, SpainHosp San Juan Dios, Dept Pediat Hematol & Oncol, Pediat Neurooncol, Passeig St Joan de Deu 2, Barcelona 08950, Spain
Morales La Madrid, Andres
Kieran, Mark W.
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机构:
Dana Farber Boston Childrens Canc & Blood Disorde, Dept Pediat Oncol, Pediat Brain Tumor Ctr, Boston, MA USAHosp San Juan Dios, Dept Pediat Hematol & Oncol, Pediat Neurooncol, Passeig St Joan de Deu 2, Barcelona 08950, Spain
机构:
Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA
Childrens Hosp, Boston, MA 02115 USAHarvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA
Samuel, David P.
Wen, Patrick Y.
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Harvard Univ, Sch Med, Dana Farber Brigham & Womens Canc Ctr, Boston, MA 02115 USAHarvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA
Wen, Patrick Y.
Kieran, Mark W.
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Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA
Childrens Hosp, Boston, MA 02115 USAHarvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA
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Columbia Univ, Dept Dermatol, Med Ctr, New York, NY 10027 USAColumbia Univ, Dept Dermatol, Med Ctr, New York, NY 10027 USA
Miller, David M.
Flaherty, Keith T.
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Massachusetts Gen Hosp, Ctr Canc, Div Hematol Oncol, Boston, MA 02114 USAColumbia Univ, Dept Dermatol, Med Ctr, New York, NY 10027 USA
Flaherty, Keith T.
Tsao, Hensin
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机构:
Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
Massachusetts Gen Hosp, MGH Canc Ctr, Dept Dermatol, Boston, MA 02114 USAColumbia Univ, Dept Dermatol, Med Ctr, New York, NY 10027 USA
机构:
Univ Paris, Hop Cochin, AP HP, Dept Gastroenterol & Digest Oncol, 27 Rue Faubourg St Jacques, F-75014 Paris, FranceUniv Paris, Hop Cochin, AP HP, Dept Gastroenterol & Digest Oncol, 27 Rue Faubourg St Jacques, F-75014 Paris, France
Pellat, Anna
Cottereau, Anne Segolene
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Univ Paris, Hop Cochin, AP HP, Dept Nucl Med, 27 Rue Faubourg St Jacques, F-75014 Paris, FranceUniv Paris, Hop Cochin, AP HP, Dept Gastroenterol & Digest Oncol, 27 Rue Faubourg St Jacques, F-75014 Paris, France
Cottereau, Anne Segolene
Palmieri, Lola-Jade
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Univ Paris, Hop Cochin, AP HP, Dept Gastroenterol & Digest Oncol, 27 Rue Faubourg St Jacques, F-75014 Paris, FranceUniv Paris, Hop Cochin, AP HP, Dept Gastroenterol & Digest Oncol, 27 Rue Faubourg St Jacques, F-75014 Paris, France
Palmieri, Lola-Jade
Soyer, Philippe
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Univ Paris, Hop Cochin, AP HP, Dept Radiol, 27 Rue Faubourg St Jacques, F-75014 Paris, FranceUniv Paris, Hop Cochin, AP HP, Dept Gastroenterol & Digest Oncol, 27 Rue Faubourg St Jacques, F-75014 Paris, France
Soyer, Philippe
Marchese, Ugo
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Univ Paris, Hop Cochin, AP HP, Dept Surg, 27 Rue Faubourg St Jacques, F-75014 Paris, FranceUniv Paris, Hop Cochin, AP HP, Dept Gastroenterol & Digest Oncol, 27 Rue Faubourg St Jacques, F-75014 Paris, France
Marchese, Ugo
Brezault, Catherine
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Univ Paris, Hop Cochin, AP HP, Dept Gastroenterol & Digest Oncol, 27 Rue Faubourg St Jacques, F-75014 Paris, FranceUniv Paris, Hop Cochin, AP HP, Dept Gastroenterol & Digest Oncol, 27 Rue Faubourg St Jacques, F-75014 Paris, France
Brezault, Catherine
Coriat, Romain
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Univ Paris, Hop Cochin, AP HP, Dept Gastroenterol & Digest Oncol, 27 Rue Faubourg St Jacques, F-75014 Paris, FranceUniv Paris, Hop Cochin, AP HP, Dept Gastroenterol & Digest Oncol, 27 Rue Faubourg St Jacques, F-75014 Paris, France
机构:
Tel Aviv Univ, Dana Childrens Hosp, Dept Pediat Neurosurg, Tel Aviv Med Ctr, 6 Weizman St, IL-64239 Tel Aviv, IsraelTel Aviv Univ, Dana Childrens Hosp, Dept Pediat Neurosurg, Tel Aviv Med Ctr, 6 Weizman St, IL-64239 Tel Aviv, Israel
Roth, Jonathan
Soleman, Jehuda
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Tel Aviv Univ, Dana Childrens Hosp, Dept Pediat Neurosurg, Tel Aviv Med Ctr, 6 Weizman St, IL-64239 Tel Aviv, Israel
Univ Hosp, Div Pediat Neurosurg, Dept Neurosurg, Basel, Switzerland
Childrens Hosp Basel, Basel, SwitzerlandTel Aviv Univ, Dana Childrens Hosp, Dept Pediat Neurosurg, Tel Aviv Med Ctr, 6 Weizman St, IL-64239 Tel Aviv, Israel
Soleman, Jehuda
Paraskevopoulos, Dimitris
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Barts Hlth NHS Trust, Dept Neurosurg, St Bartholomews & Royal London Hosp, London, England
Queen Mary Univ London, Blizard Inst, Barts & London Sch Med, London, EnglandTel Aviv Univ, Dana Childrens Hosp, Dept Pediat Neurosurg, Tel Aviv Med Ctr, 6 Weizman St, IL-64239 Tel Aviv, Israel
Paraskevopoulos, Dimitris
Keating, Robert F.
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Childrens Natl Med Ctr, Dept Neurosurg, Washington, DC 20010 USA
Childrens Natl Med Ctr, Dept Pediat, Washington, DC 20010 USATel Aviv Univ, Dana Childrens Hosp, Dept Pediat Neurosurg, Tel Aviv Med Ctr, 6 Weizman St, IL-64239 Tel Aviv, Israel
Keating, Robert F.
Constantini, Shlomi
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Tel Aviv Univ, Dana Childrens Hosp, Dept Pediat Neurosurg, Tel Aviv Med Ctr, 6 Weizman St, IL-64239 Tel Aviv, IsraelTel Aviv Univ, Dana Childrens Hosp, Dept Pediat Neurosurg, Tel Aviv Med Ctr, 6 Weizman St, IL-64239 Tel Aviv, Israel
机构:
St Jude Childrens Res Hosp, Div Neurol, 332 N Lauderdale St, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Div Neurol, 332 N Lauderdale St, Memphis, TN 38105 USA
Khan, Raja B.
Bano, Maha
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Univ Tennessee, Dept Pediat, Memphis, TN USASt Jude Childrens Res Hosp, Div Neurol, 332 N Lauderdale St, Memphis, TN 38105 USA
Bano, Maha
Wang, Fang
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机构:
St Jude Childrens Res Hosp, Dept Biostat, 332 N Lauderdale St, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Div Neurol, 332 N Lauderdale St, Memphis, TN 38105 USA
Wang, Fang
Haitao, Pan
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机构:
St Jude Childrens Res Hosp, Dept Biostat, 332 N Lauderdale St, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Div Neurol, 332 N Lauderdale St, Memphis, TN 38105 USA
Haitao, Pan
Christensen, Anthony
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机构:
St Jude Childrens Res Hosp, Pharmaceut Serv, 332 N Lauderdale St, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Div Neurol, 332 N Lauderdale St, Memphis, TN 38105 USA
Christensen, Anthony
Smith, Jessica
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St Jude Childrens Res Hosp, Div Neurol, 332 N Lauderdale St, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Div Neurol, 332 N Lauderdale St, Memphis, TN 38105 USA
Smith, Jessica
Simmons, Andrea
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St Jude Childrens Res Hosp, Div Neurol, 332 N Lauderdale St, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Div Neurol, 332 N Lauderdale St, Memphis, TN 38105 USA
Simmons, Andrea
Sadighi, Zsila S.
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机构:
Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Houston, TX 77030 USASt Jude Childrens Res Hosp, Div Neurol, 332 N Lauderdale St, Memphis, TN 38105 USA