Probabilistic regulation of IL-4 production

被引：11

作者：

Guo, LY ^{[1
]}

Hu-Li, J ^{[1
]}

Paul, WE ^{[1
]}

机构：

[1] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2005年 / 25卷 / 06期

关键词：

cytokines; chromatin; monoallelism; green florescence protein;

D O I：

10.1007/s10875-005-8218-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Among a population of uniformly differentiated TH2 cells, only a portion express IL-4 upon stimulation and those that do often express the product of only a single allele. We review the evidence for the basis of IL-4 monoallelism and argue that it depends upon probabilistic expression of the Il4 gene. Further, we argue that probabilistic expression may provide a powerful mechanism through which certain key functions of IL-4, such as immunoglobulin class switching and determination of macrophage phenotype, may be efficiently regulated.

引用

收藏

页码：573 / 581

页数：9

相关论文

共 33 条

[1] Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation [J].

Agarwal, S ;

Rao, A .

IMMUNITY, 1998, 9 (06) :765-775

[2] Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo [J].

Agarwal, S ;

Avni, O ;

Rao, A .

IMMUNITY, 2000, 12 (06) :643-652

[3] Analysis of allelic expression patterns of IL-2, IL-3 IL-4, and IL-13 in human CD4+ T cell clones [J].

Bayley, JP ;

Bakker, AM ;

Kaijzel, EL ;

Wierenga, EA ;

van der Pouw-Kraan, TCTM ;

Huizinga, TWJ ;

Verweij, CL .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (08) :2142-2148

[4] Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells [J].

Bix, M ;

Locksley, RM .

SCIENCE, 1998, 281 (5381) :1352-1354

[5]

COFFMAN RL, 1986, J IMMUNOL, V136, P4538

[6] Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region [J].

Fields, PE ;

Lee, GR ;

Kim, ST ;

Bartsevich, VV ;

Flavell, RA .

IMMUNITY, 2004, 21 (06) :865-876

[7] HUMAN B-CELL CLONES CAN BE INDUCED TO PROLIFERATE AND TO SWITCH TO IGE AND IGG4 SYNTHESIS BY INTERLEUKIN-4 AND A SIGNAL PROVIDED BY ACTIVATED CD4+ T-CELL CLONES [J].

GASCAN, H ;

GAUCHAT, JF ;

RONCAROLO, MG ;

YSSEL, H ;

SPITS, H ;

DEVRIES, JE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (03) :747-750

[8] Replicating by the clock [J].

Goren, A ;

Cedar, H .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (01) :25-32

[9] Probabilistic regulation in TH2 cells accounts for monoallelic expression of IL-4 and IL-13 [J].

Guo, LY ;

Hu-Li, J ;

Paul, WE .

IMMUNITY, 2005, 23 (01) :89-99

[10] Probabilistic regulation of IL-4 production in Th2 cells: Accessibility at the Il4 locus [J].

Guo, LY ;

Hu-Li, J ;

Paul, WE .

IMMUNITY, 2004, 20 (02) :193-203

← 1 2 3 4 →