Nickel-catalyzed cyanation reaction of aryl/alkenyl halides with alkyl isocyanides

被引：12

作者：

Zhang, Yanling ^{[1
]}

Zhang, Zhiguo ^{[1
]}

Hu, Yuanyuan ^{[1
]}

Liu, Yunkui ^{[1
]}

Jin, Hongwei ^{[1
]}

Zhou, Bingwei ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 41期

基金：

中国国家自然科学基金;

关键词：

C-H CYANATION; ARYL HALIDES; EFFICIENT CATALYSTS; COUPLING REACTIONS; TERMINAL ALKYNES; NITRILES; MILD; PD; COMPLEXES; BROMIDES;

D O I：

10.1039/d2ob01240e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We herein describe a nickel-catalyzed cyanation reaction of aryl/alkenyl halides with alkyl isocyanides. Both aryl/alkenyl iodines and bromides were found to be competent electrophiles that reacted with alkyl isocyanides, affording nitrile compounds in moderate to good yields. A range of functional groups including halogens as well as hydroxyl, formyl, and acetamino groups were fairly compatible with the nickel catalysis. This protocol featured broad functional group tolerance, simple reaction conditions, and gram-scale synthesis.

引用

页码：8049 / 8053

页数：5

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