Efficacy of adjuvant radiotherapy for atypical and anaplastic meningioma

被引:67
|
作者
Zhu, Hongda [1 ]
Bi, Wenya Linda [2 ]
Aizer, Ayal [3 ]
Hua, Lingyang [1 ]
Tian, Mi [5 ]
Den, Jiaojiao [1 ]
Tang, Hailiang [1 ]
Chen, Hong [4 ]
Wang, Yin [4 ]
Mao, Ying [1 ]
Dunn, Ian F. [2 ]
Xie, Qing [1 ]
Gong, Ye [1 ,5 ]
机构
[1] Fudan Univ, Dept Neurosurg, Huashan Hosp, Shanghai, Peoples R China
[2] Harvard Med Sch, Dept Neurosurg, Ctr Skull Base & Pituitary Surg, Brigham & Womens Hosp, Boston, MA USA
[3] Harvard Med Sch, Dept Radiat Oncol, Brigham & Womens Hosp, Boston, MA USA
[4] Fudan Univ, Dept Neuropathol, Huashan Hosp, Shanghai, Peoples R China
[5] Fudan Univ, Dept Crit Care Med, Huashan Hosp, Shanghai, Peoples R China
来源
CANCER MEDICINE | 2019年 / 8卷 / 01期
基金
中国国家自然科学基金;
关键词
anaplastic meningioma; atypical meningioma; overall survival; progression-free survival; radiation therapy; MALIGNANT MENINGIOMAS; RECURRENCE; SURVIVAL; CLASSIFICATION; RESECTION; OUTCOMES; SURGERY;
D O I
10.1002/cam4.1531
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The effect of adjuvant radiotherapy in management for high-grade meningiomas, especially atypical meningiomas, remains controversial. We aimed to explore the role of adjuvant radiotherapy in this population. A total of 162 adults with high-grade meningiomas (99 atypical meningiomas and 63 anaplastic meningiomas) were treated from 2003 to 2008 at Huashan Hospital. One hundred and seventeen patients presented with primary and 45 with recurrent disease. One hundred and fifteen patients (70.9%) were treated with adjuvant radiotherapy after surgical resection. The median follow-up was 76.5 months (range 1-142 months). Kaplan-Meier survival curve and Cox proportional hazards modeling were used for analyses. Adjuvant radiotherapy was associated with prolonged progression-free survival (PFS) and overall survival (OS) in patients with newly diagnosed anaplastic meningiomas irrespective of extent of resection (PFS, P = .001; OS, P = .003). Gross total resection was the only independent prognostic factor for those with newly diagnosed atypical meningiomas (PFS, P OS, P = .012). A survival benefit for adjuvant radiation was also found in subgroup analysis of patients with high-grade meningiomas who underwent subtotal resection (PFS, P = .023; OS, P = .013). Among recurrent high-grade meningiomas, radiotherapy offered no statistically significant improvement in either PFS or OS. Adjuvant radiotherapy is associated with improved survival in patients with newly diagnosed anaplastic meningiomas and those high-grade meningiomas following subtotal resection. However, there was no significant correlation identified between postoperative radiation and outcome for recurrent high-grade meningiomas. Future prospective randomized trials may help clarify the optimal tailored treatment for patients with high-grade meningioma.
引用
收藏
页码:13 / 20
页数:8
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