New calix[4]arenes having electron donating groups at the upper rim as molecular platforms and host molecules

A new and general synthetic procedure for the exhaustive and selective introduction of hydroxy groups at the upper rim of calix[4]arenes in the cone conformation is reported. The aldehyde-derivatives of tetraalkoxycalix[4]arenes have been oxidized by Baeyer-Villiger reaction. The introduction of amino and hydroxy groups on calix[4]arene having a rigid cone conformation has been achieved for the first time. Copyright (C) 1996 Elsevier Science Ltd