A Lewis Acid Palladium(II)-Catalyzed Three-Component Synthesis of α-Substituted Amides

被引：36

作者：

Beisel, Tamara ^{[1
]}

Manolikakes, Georg ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Dept Organ Chem & Chem Biol, D-60054 Frankfurt, Germany

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 23期

关键词：

CATALYZED ASYMMETRIC ARYLATION; N-ACYLIMINIUM IONS; ARYLBORONIC ACIDS; PETASIS REACTION; IMINES; AMINES; DERIVATIVES; ALKYLATION; ALDEHYDES; ALCOHOLS;

D O I：

10.1021/ol402949t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Lewis acid palladium-catalyzed reaction of amides, aryl aldehydes, and arylboronic acids is described. This new method allows for a practical and general synthesis of alpha-substituted amides from simple, readily available building blocks.

引用

页码：6046 / 6049

页数：4

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