Synthesis, Antibacterial, and Antiviral Evaluation of New Heterocycles Containing the Pyridine Moiety

被引：65
|
作者：
Salem, Marwa S. [1 ]
Sakr, Sameh I. [1 ]
El-Senousy, Waled M. [2 ]
Madkour, Hassan M. F. [1 ]
机构：
[1] Ain Shams Univ, Dept Chem, Synthet Organ Chem Lab, Fac Sci, Cairo 11566, Egypt
[2] NRC, Water Pollut Res Dept, Cairo, Egypt
来源：
ARCHIV DER PHARMAZIE | 2013年 / 346卷 / 10期
关键词：
Antimicrobial activity; Antivirus activity; Furo[2; 3-b]pyridine; Nicotinonitrile; 2-Pyridone; ENAMINONITRILE MOIETY; INHIBITORS; DERIVATIVES; ANTICANCER; CHEMISTRY; PYRIDONE; UTILITY;
D O I：
10.1002/ardp.201300183
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A facile one-pot four-component reaction was utilized to construct 2-oxo-1,2-dihydropyridine-3-carbonitrile as a scaffold for the synthesis of many fused heterocyclic systems, namely, furopyridine, pyridothiadiazepinthione, and pyridotriazine, as well as non-fused heterocyclic systems such as phthalazin-2(1H)-ylnicotinonitrile, pyridin-2-yl-1H-pyrazole, and pyrazol-1-ylnicotino-nitrile,1-(3-cyanopyridin-2-yl)-1H-pyrazole. The new compounds were evaluated as antimicrobial and antiviral agents.
引用
收藏
页码：766 / 773
页数：8
相关论文
共 50 条
  • [41] Manganese(II) Macrocyclic Schiff-Base Complexes Containing Pyridine Moiety: Synthesis and Characterization and Antibacterial Properties
    Hassan, Keypour
    Mozhdeh, Liyaghati-Delshad
    Majid, Rezaeivala
    Reza, Khavasi Hamid
    CHINESE JOURNAL OF INORGANIC CHEMISTRY, 2014, 30 (07) : 1733 - 1740
  • [42] Synthesis and antibacterial evaluation of some new pyrimidine, pyridine and thiophene derivatives
    El-Shareef, Ahmed A. M.
    Hussein, Abdel Haleem M.
    El-Adasy, Abu-Bakr A. M.
    Othman, Ismail M.
    Khames, Ahmed A.
    EGYPTIAN JOURNAL OF CHEMISTRY, 2021, 64 (07): : 3691 - 3701
  • [43] Design, Synthesis, and Bioactivity of Spiro Derivatives Containing a Pyridine Moiety
    Yu, Lijiao
    Guo, Shengxin
    Wang, Ya
    Liao, Anjing
    Zhang, Wei
    Sun, Ping
    Wu, Jian
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2022, 70 (50) : 15726 - 15736
  • [44] Synthesis and antiviral activities of amide derivatives containing the α-aminophosphonate moiety
    Hu, De-Yu
    Wan, Qiong-Qiong
    Yang, Song
    Song, Bao-An
    Bhadury, Pinaki S.
    Jin, Lin-Hong
    Yan, Kai
    Liu, Fang
    Chen, Zhuo
    Xue, Wei
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (03) : 998 - 1001
  • [45] Synthesis and Antiviral Activities of Pyrazole Derivatives Containing an Oxime Moiety
    Ouyang, Guiping
    Cai, Xue-Jian
    Chen, Zhuo
    Song, Bao-An
    Bhadury, Pinaki S.
    Yang, Song
    Jin, Lin-Hong
    Xue, Wei
    Hu, De-Yu
    Zeng, Song
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (21) : 10160 - 10167
  • [46] Synthesis and antiviral activities of cyanoacrylate derivatives containing an α-aminophosphonate moiety
    Long, Ning
    Cai, Xue-Jian
    Song, Bao-An
    Yang, Song
    Chen, Zhuo
    Bhadury, Pinaki S.
    Hu, De-Yu
    Jin, Lin-Hong
    Xue, Wei
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (13) : 5242 - 5246
  • [47] Synthesis and Antiviral Activity of Novel α-Aminophosphorus Containing Benzofuran Moiety
    Tang, Chenghao
    Chen, Zhiwei
    Xiao, Han
    Wang, Xiang
    Zhang, Guoping
    Hu, Deyu
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2015, 190 (04) : 585 - 595
  • [48] Synthesis and Antiviral Activities of α-Aminophosphonate Derivatives Containing a Pyridazine Moiety
    Zhou, Jun
    Fan, Hui-Tao
    Song, Bao-An
    Jin, Lin-Hong
    Bhadury, Pinaki S.
    Hu, De-Yu
    Yang, Song
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2011, 186 (01) : 81 - 87
  • [49] Synthesis and antiviral activities of amide derivatives containing the α-aminophosphonate moiety
    Hu, De-Yu
    Wan, Qiong-Qiong
    Yang, Song
    Song, Bao-An
    Bhadury, Pinaki S.
    Jin, Lin-Hong
    Yan, Kai
    Liu, Fang
    Chen, Zhuo
    Xue, Wei
    Journal of Agricultural and Food Chemistry, 2008, 56 (03): : 998 - 1001
  • [50] Synthesis; antibacterial and antifungal activities of some new azo anils containing pyrazole moiety
    Sharma, S.
    Kaur, Jasvir
    Kaur, Sandeep
    Sharma, Poonam
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2014, 53 (02): : 227 - 237
12345