Synthesis, Antibacterial, and Antiviral Evaluation of New Heterocycles Containing the Pyridine Moiety

被引：65
|
作者：
Salem, Marwa S. [1 ]
Sakr, Sameh I. [1 ]
El-Senousy, Waled M. [2 ]
Madkour, Hassan M. F. [1 ]
机构：
[1] Ain Shams Univ, Dept Chem, Synthet Organ Chem Lab, Fac Sci, Cairo 11566, Egypt
[2] NRC, Water Pollut Res Dept, Cairo, Egypt
来源：
ARCHIV DER PHARMAZIE | 2013年 / 346卷 / 10期
关键词：
Antimicrobial activity; Antivirus activity; Furo[2; 3-b]pyridine; Nicotinonitrile; 2-Pyridone; ENAMINONITRILE MOIETY; INHIBITORS; DERIVATIVES; ANTICANCER; CHEMISTRY; PYRIDONE; UTILITY;
D O I：
10.1002/ardp.201300183
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A facile one-pot four-component reaction was utilized to construct 2-oxo-1,2-dihydropyridine-3-carbonitrile as a scaffold for the synthesis of many fused heterocyclic systems, namely, furopyridine, pyridothiadiazepinthione, and pyridotriazine, as well as non-fused heterocyclic systems such as phthalazin-2(1H)-ylnicotinonitrile, pyridin-2-yl-1H-pyrazole, and pyrazol-1-ylnicotino-nitrile,1-(3-cyanopyridin-2-yl)-1H-pyrazole. The new compounds were evaluated as antimicrobial and antiviral agents.
引用
收藏
页码：766 / 773
页数：8
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