Synthesis, Antibacterial, and Antiviral Evaluation of New Heterocycles Containing the Pyridine Moiety

被引：67

作者：

Salem, Marwa S. ^{[1
]}

Sakr, Sameh I. ^{[1
]}

El-Senousy, Waled M. ^{[2
]}

Madkour, Hassan M. F. ^{[1
]}

机构：

[1] Ain Shams Univ, Dept Chem, Synthet Organ Chem Lab, Fac Sci, Cairo 11566, Egypt

[2] NRC, Water Pollut Res Dept, Cairo, Egypt

来源：

ARCHIV DER PHARMAZIE | 2013年 / 346卷 / 10期

关键词：

Antimicrobial activity; Antivirus activity; Furo[2; 3-b]pyridine; Nicotinonitrile; 2-Pyridone; ENAMINONITRILE MOIETY; INHIBITORS; DERIVATIVES; ANTICANCER; CHEMISTRY; PYRIDONE; UTILITY;

D O I：

10.1002/ardp.201300183

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A facile one-pot four-component reaction was utilized to construct 2-oxo-1,2-dihydropyridine-3-carbonitrile as a scaffold for the synthesis of many fused heterocyclic systems, namely, furopyridine, pyridothiadiazepinthione, and pyridotriazine, as well as non-fused heterocyclic systems such as phthalazin-2(1H)-ylnicotinonitrile, pyridin-2-yl-1H-pyrazole, and pyrazol-1-ylnicotino-nitrile,1-(3-cyanopyridin-2-yl)-1H-pyrazole. The new compounds were evaluated as antimicrobial and antiviral agents.

引用

页码：766 / 773

页数：8

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