New Insights into the Role of Erythrocytes in Thrombus Formation

被引：57
作者：
Du, Vivian X. [1 ,2 ]
Huskens, Dana [3 ,4 ]
Maas, Coen [1 ]
Al Dieri, Raed [3 ,4 ]
de Groot, Philip G. [1 ]
de Laat, Bas [1 ,2 ,3 ,4 ]
机构：
[1] Univ Med Ctr, Dept Clin Chem & Hematol, NL-3584 CX Utrecht, Netherlands
[2] Sanquin Res, Amsterdam, Netherlands
[3] Univ Maastricht, Cardiovasc Res Inst Maastricht, Maastricht, Netherlands
[4] Synapse BV, Maastricht, Netherlands
来源：
SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2014年 / 40卷 / 01期
关键词：
erythrocyte; thrombosis; hemostasis; coagulation; thrombin; RED-BLOOD-CELLS; VON-WILLEBRAND-FACTOR; PHOSPHATIDYLSERINE EXPOSURE; ADHESION MOLECULE; ENDOTHELIAL-CELLS; PROCOAGULANT ACTIVITY; SICKLE RETICULOCYTES; PLATELET ACTIVATION; FACTOR-XI; MEMBRANE;
D O I：
10.1055/s-0033-1363470
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The role of erythrocytes in thrombus formation has previously been regarded as passive by their influence on rheology. Erythrocytes are known, due to their abundance and size, to push platelets to the vascular wall (laminar shearing). This results in an increased platelet delivery at the vascular wall enabling platelets to seal off a vascular damage preventing excessive blood loss. Recently, there is new evidence for erythrocytes to influence thrombus formation in multiple ways besides their effect on rheology. Several groups have shown that besides platelets, erythrocytes are the main suppliers of phosphatidylserine-exposing membranes needed for coagulation resulting in fibrin formation. In addition, our group has found that the intercellular adhesion molecule 4-(IIb3) interaction mediates erythrocyte-platelet interaction in flowing blood. By inhibiting this interaction, we found decreased thrombin formation and decreased incorporation of erythrocytes into a thrombus. This review will provide more in-detail information of existing and new hypotheses regarding the role of erythrocytes in thrombus formation.
引用
收藏
页码：72 / 80
页数：9
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