Ligand-Free Copper-Catalyzed One-Pot Synthesis of Indole-2-carboxylic Esters

被引：15

作者：

Zhu, Zhiqiang ^{[1
]}

Yuan, Jiangjun ^{[2
,3
]}

Zhou, Yirong ^{[2
,3
]}

Qin, Yang ^{[2
,3
]}

Xu, Jingshi ^{[1
]}

Peng, Yiyuan ^{[1
,2
,3
]}

机构：

[1] Jiangxi Normal Univ, Jiangxi Prov & Coll Chem, Key Lab Green Chem, Nanchang 330022, Jiangxi, Peoples R China

[2] Jiangxi Normal Univ, Minist Educ, Key Lab Small Fuct Organ Mol, Nanchang 330022, Jiangxi, Peoples R China

[3] Jiangxi Normal Univ, Coll Life Sci, Nanchang 330022, Jiangxi, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Synthetic methods; Domino reactions; Nitrogen heterocycles; Copper; SIMPLE INDOLE ALKALOIDS; SOLID-PHASE SYNTHESIS; C-H BONDS; NATURAL-PRODUCTS; N-ARYLATION; AMINATION REACTIONS; EFFICIENT SYNTHESIS; COUPLING REACTIONS; CASCADE SYNTHESIS; FACILE SYNTHESIS;

D O I：

10.1002/ejoc.201301607

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, efficient, and facile synthetic route for the preparation of indole-2-carboxylic esters was described. The cascade reactions of 2-bromobenzaldehyde and glycine ester hydrochloride were promoted by Cu2O and a base to provide the corresponding products in good yields. Commercially available, inexpensive substrates and reagents were employed under mild reaction conditions in this one-pot operation, which is complementary to existing methods for access to 2-substituted indoles.

引用

页码：511 / 514

页数：4

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