Whispering gallery mode biosensor operated in the stimulated emission regime

被引：73
|
作者：
Francois, Alexandre [1 ]
Himmelhaus, Michael [1 ]
机构：
[1] FUJIREBIO Inc, Div Res & Dev, Hachioji, Tokyo 1920031, Japan
来源：
APPLIED PHYSICS LETTERS | 2009年 / 94卷 / 03期
关键词：
adsorption; biosensors; chemical sensors; micromechanical resonators; optical sensors; whispering gallery modes; MICROCAVITY; MICROSPHERE; RESONATORS; MOLECULES; SENSORS; SHIFT; CHIP;
D O I：
10.1063/1.3059573
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
Whispering gallery modes (WGMs) are generated in fluorescent polymer microparticles in phosphate buffered saline (PBS) above the threshold for stimulated emission and compared to their characteristics below threshold. The WGM microresonators show an eightfold improvement of their signal-to-noise ratio and a threefold increase in their quality factor when operated above threshold. In an investigation on the benefits for biochemical sensing, a real-time adsorption kinetics of bovine serum albumin in PBS is monitored and compared with those kinetics acquired by means of a WGM microresonator operated below threshold as well as by surface plasmon resonance (SPR).
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页数：3
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