QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor

被引：18
|
作者：
Macchiarulo, A
De Luca, L
Costantino, G
Barreca, ML
Gitto, R
Pellicciari, R
Chimirri, A
机构：
[1] Univ Messina, Dipartimento Farmacochim, I-98168 Messina, Italy
[2] Univ Perugia, Dipartimento Chim & Tecnol Farmaco, I-06123 Perugia, Italy
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 47卷 / 07期
关键词：
D O I：
10.1021/jm0310838
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A quantitative structure-activity relationship (QSAR) study was performed on a set of 49 negative allosteric modulators of AMPA receptor, acting as anticonvulsant agents, using multiple linear regression. The predictive ability of the resulting model was evaluated against a set of 12 compounds; the results showed good statistics in regression and revealed high correlation between anticonvulsant activity and some electrotopological descriptors.
引用
收藏
页码：1860 / 1863
页数：4
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