QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor

被引：18

作者：

Macchiarulo, A

De Luca, L

Costantino, G

Barreca, ML

Gitto, R

Pellicciari, R

Chimirri, A

机构：

[1] Univ Messina, Dipartimento Farmacochim, I-98168 Messina, Italy

[2] Univ Perugia, Dipartimento Chim & Tecnol Farmaco, I-06123 Perugia, Italy

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 47卷 / 07期

关键词：

D O I：

10.1021/jm0310838

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A quantitative structure-activity relationship (QSAR) study was performed on a set of 49 negative allosteric modulators of AMPA receptor, acting as anticonvulsant agents, using multiple linear regression. The predictive ability of the resulting model was evaluated against a set of 12 compounds; the results showed good statistics in regression and revealed high correlation between anticonvulsant activity and some electrotopological descriptors.

引用

页码：1860 / 1863

页数：4

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