Knocking Out Sigma-1 Receptors Reveals Diverse Health Problems

被引：34

作者：

Couly, Simon ^{[1
]}

Goguadze, Nino ^{[1
]}

Yasui, Yuko ^{[1
]}

Kimura, Yuriko ^{[1
]}

Wang, Shao-Ming ^{[1
]}

Sharikadze, Nino ^{[1
]}

Wu, Hsiang-En ^{[1
]}

Su, Tsung-Ping ^{[1
]}

机构：

[1] NIDA, Cellular Pathobiol Sect, Integrat Neurosci Branch, Intramural Res Program,DHHS,IRP,NIH,Triad Technol, 333 Cassell Dr, Baltimore, MD 21224 USA

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2022年 / 42卷 / 03期

关键词：

Sigma-1; receptor; Endoplasmic reticulum; Mitochondria; Neurodegenerative disorders; DORSAL-ROOT GANGLION; ENDOPLASMIC-RETICULUM; KNOCKOUT MICE; DEPRESSIVE-LIKE; MOUSE MODEL; BEHAVIORAL DESPAIR; CARDIAC MYOCYTES; ALCOHOL-DRINKING; OXIDATIVE STRESS; NEUROPATHIC PAIN;

D O I：

10.1007/s10571-020-00983-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sigma-1 receptor (Sig-1R) is a protein present in several organs such as brain, lung, and heart. In a cell, Sig-1R is mainly located across the membranes of the endoplasmic reticulum and more specifically at the mitochondria-associated membranes. Despite numerous studies showing that Sig-1R could be targeted to rescue several cellular mechanisms in different pathological conditions, less is known about its fundamental relevance. In this review, we report results from various studies and focus on the importance of Sig-1R in physiological conditions by comparing Sig-1R KO mice to wild-type mice in order to investigate the fundamental functions of Sig-1R. We note that the Sig-1R deletion induces cognitive, psychiatric, and motor dysfunctions, but also alters metabolism of heart. Finally, taken together, observations from different experiments demonstrate that those dysfunctions are correlated to poor regulation of ER and mitochondria metabolism altered by stress, which could occur with aging.

引用

页码：597 / 620

页数：24

共 146 条

[101] Neuroprotective effects of the Sigma-1 receptor (SIR) agonist PRE-084, in a mouse model of moter neuron disease not linked to SOD1 mutation [J].