Morphological and Immunophenotypic Clues to the WHO Categories of Acute Myeloid Leukaemia

被引：68

作者：

Bain, Barbara J. ^{[1
]}

Bene, Marie C. ^{[2
]}

机构：

[1] St Marys Hosp, Dept Haematol, Praed St, London W2 1NY, England

[2] Nantes Univ Hosp, Hematol Biol, Nantes, France

来源：

ACTA HAEMATOLOGICA | 2019年 / 141卷 / 04期

关键词：

Acute myeloid leukaemia; Immunophenotyping; Morphology; World Health Organisation classification; FLOW-CYTOMETRY; ANTIGEN EXPRESSION; FLT3; ASSOCIATION; MUTATIONS; FEATURES; PROFILE; CD34; CD56; NPM1;

D O I：

10.1159/000496097

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diagnosis and classification of acute myeloid leukaemia (AML) require cytogenetic and molecular genetic investigation. However, while these evaluations are pending, morphology supplemented by immunophenotyping can provide clues to the diagnosis of specific cytogenetic/genetic categories of AML. Most importantly, acute promyelocytic leukaemia can be diagnosed with a high degree of certainty. However, provisional identification of cases associated with t(8;21), inv(16), t(1;22), and NPM1 mutation may also be possible. In addition, transient abnormal myelopoiesis of Down's syndrome can generally be diagnosed morphologically. (c) 2019 S. Karger AG, Basel

引用

页码：232 / 244

页数：13

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