The role of Muller glia and microglia in glaucoma

被引：73
|
作者：
Seitz, Roswitha [1 ]
Ohlmann, Andreas [1 ]
Tamm, Ernst R. [1 ]
机构：
[1] Univ Regensburg, Inst Human Anat & Embryol, D-93053 Regensburg, Germany
来源：
CELL AND TISSUE RESEARCH | 2013年 / 353卷 / 02期
关键词：
Glaucoma; Microglia; Muller glia; Neuroprotection; Retina; RETINAL GANGLION-CELLS; TUMOR-NECROSIS-FACTOR; CILIARY NEUROTROPHIC FACTOR; OPTIC-NERVE HEAD; LEUKEMIA INHIBITORY FACTOR; FIBRILLARY ACIDIC PROTEIN; NITRIC-OXIDE PRODUCTION; MOUSE MODEL; UP-REGULATION; IN-VIVO;
D O I：
10.1007/s00441-013-1666-y
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cells of Muller glia and microglia react to neuronal injury in glaucoma. The change to a reactive phenotype initiates signaling cascades that may serve a neuroprotective role, but may also proceed to promote damaging effects on retinal neurons. Both effects appear to occur most likely in parallel in glaucoma, but the underlying mechanisms and signaling pathways that specifically promote protective versus destructive roles of reactive glial cells are mostly unclear. More research is needed to understand the homeostatic signaling network in which retinal glia cells are embedded to maintain or restore neuronal function after injury.
引用
收藏
页码：339 / 345
页数：7
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