Intravenous immunoglobulin therapy: how does IgG modulate the immune system?

被引：629

作者：

Schwab, Inessa ^{[1
]}

Nimmerjahn, Falk ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Inst Genet, Dept Biol, D-91058 Erlangen, Germany

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 03期

关键词：

FC-GAMMA-RECEPTOR; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IVIG-MEDIATED AMELIORATION; ANTI-D IMMUNOGLOBULIN; HIGH-AFFINITY BINDING; REGULATORY T-CELLS; ANTIINFLAMMATORY ACTIVITY; B-CELLS; RHEUMATOID-ARTHRITIS; DENDRITIC CELLS;

D O I：

10.1038/nri3401

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intravenous immunoglobulin (IVIG) preparations comprise pooled IgG antibodies from the serum of thousands of donors and were initially used as an IgG replacement therapy in immunocompromised patients. Since the discovery, more than 30 years ago, that IVIG therapy can ameliorate immune thrombocytopenia, the use of IVIG preparations has been extended to a wide range of autoimmune and inflammatory diseases. Despite the broad efficacy of IVIG therapy, its modes of action remain unclear. In this Review, we cover the recent insights into the molecular and cellular pathways that are involved in IVIG-mediated immunosuppression, with a particular focus on IVIG as a therapy for IgG-dependent autoimmune diseases.

引用

页码：176 / 189

页数：14

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