Direct Access to 2,3-Disubstituted Amido-Indenones through Annulation of 2-Iodobenzaldehydes with Ynamides

被引：5
|
作者：
Golling, Stephane [1 ]
Hansjacob, Pierre [1 ]
Bami, Nassim [1 ]
Leroux, Frederic R. [1 ]
Donnard, Morgan [1 ]
机构：
[1] Univ Haute Alsace, CNRS, UMR 7042 LIMA, ECPM, F-67000 Strasbourg, France
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 24期
关键词：
PALLADIUM-CATALYZED ANNULATION; CYCLIZATION; CHEMISTRY; ALKYNES;
D O I：
10.1021/acs.joc.2c02054
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this paper we report the annulation reaction between 2-iodobenzaldehyde derivatives and various ynamides. This palladium-catalyzed reaction leads to rare polysubstituted amino-indenones in good yields with a regioselectivity up to complete. Remarkably, a regiodivergent selectivity has been identified between aryl and alkyl or silyl ynamides, with the first leading mainly to 2-amido-indenones and the second to 3-amido-indenones.
引用
收藏
页码：16860 / 16866
页数：7
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